Deoxynivalenol induces apoptosis in mouse thymic epithelial cells through mitochondria-mediated pathway

Highlights • Deoxynivalenol (DON) can induce apoptosis in mouse thymic epithelial cell line 1 (MTEC1). • DON can increase the protein levels of p53 in MTEC1 cells. • DON can increase reactive oxygen species levels and decrease mitochondrial membrane potential in MTEC1 cells. • DON can increase the e...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2014-07, Vol.38 (1), p.163-171
Hauptverfasser:	Li, Daotong, Ma, Haoran, Ye, Yaqiong, Ji, Changyun, Tang, Xiaohong, Ouyang, Dan, Chen, Jian, Li, Yugu, Ma, Yongjiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Caspases - metabolism Cell Line Deoxynivalenol Emergency Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - physiology Membrane Potential, Mitochondrial - drug effects Mice Mitochondria - drug effects Mitochondria - physiology Mitochondrial MTEC1 cells P53 Poly(ADP-ribose) Polymerases - metabolism Reactive Oxygen Species - metabolism ROS Thymus Gland - cytology Trichothecenes - toxicity Tumor Suppressor Protein p53 - metabolism
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Zusammenfassung:	Highlights • Deoxynivalenol (DON) can induce apoptosis in mouse thymic epithelial cell line 1 (MTEC1). • DON can increase the protein levels of p53 in MTEC1 cells. • DON can increase reactive oxygen species levels and decrease mitochondrial membrane potential in MTEC1 cells. • DON can increase the expression levels of apoptosis-associated proteins in MTEC1 cells.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2014.05.015