Effect of Heat Shock Protein 90 (Hsp90) on Migration and Invasion of Human Cancer Cells in Vitro

We studied the effect of purifi ed native heat shock protein 90 (Hsp90) from bovine and mouse brain on migration and invasion of human glioblastoma (A-172) and fi brosarcoma (HT1080) cells. Hsp90 in concentrations of 0.01-0.10 mg/ml stimulated migration and invasion of tumor cells in vitro by 20-32%...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2014-08, Vol.157 (4), p.476-478
Hauptverfasser:	Snigireva, A. V., Vrublevskaya, V. V., Skarga, Yu. Yu, Evdokimovskaya, Yu. V., Morenkov, O. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - pharmacology Biomedical and Life Sciences Biomedicine Brain Chemistry Cancer Cattle Cell Biology Cell Line, Tumor Cell Movement - drug effects Diffusion Chambers, Culture Extracellular Matrix Proteins - pharmacology Fibroblasts - cytology Fibroblasts - drug effects Heat shock proteins HSP70 Heat-Shock Proteins - antagonists & inhibitors HSP70 Heat-Shock Proteins - isolation & purification HSP70 Heat-Shock Proteins - pharmacology HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - isolation & purification HSP90 Heat-Shock Proteins - pharmacology Internal Medicine Laboratory Medicine Mice Neuroglia - cytology Neuroglia - drug effects NIH 3T3 Cells Pathology Sarcoma
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Zusammenfassung:	We studied the effect of purifi ed native heat shock protein 90 (Hsp90) from bovine and mouse brain on migration and invasion of human glioblastoma (A-172) and fi brosarcoma (HT1080) cells. Hsp90 in concentrations of 0.01-0.10 mg/ml stimulated migration and invasion of tumor cells in vitro by 20-32% ( p
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-014-2595-9