Effects of transcranial direct current stimulation on esophageal motility in patients with gastroesophageal reflux disease

Highlights • Prolonged excitatory tDCS over the esophageal motor cortical cortex can significantly modify esophageal peristalsis in gastroesophageal reflux disease (GERD) patients. • Anodal tDCS have shown a strong effect on distal waves mean amplitude and percentage of pathological waves in patient...

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Veröffentlicht in:	Clinical neurophysiology 2014-09, Vol.125 (9), p.1840-1846
Hauptverfasser:	Vigneri, Simone, Bonventre, Sebastiano, Inviati, Angela, Schifano, Domenico, Cosentino, Giuseppe, Puma, Angela, Giglia, Giuseppe, Paladino, Piera, Brighina, Filippo, Fierro, Brigida
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Distal amplitude Double-Blind Method Electrodes ERD Esophageal Motility Disorders - physiopathology Esophagus - physiopathology Female Gastroesophageal Reflux - physiopathology Humans Hydrogen-Ion Concentration Male Manometry Middle Aged NERD Neurology Pathological waves Sensitization tDCS Transcranial Direct Current Stimulation
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Zusammenfassung:	Highlights • Prolonged excitatory tDCS over the esophageal motor cortical cortex can significantly modify esophageal peristalsis in gastroesophageal reflux disease (GERD) patients. • Anodal tDCS have shown a strong effect on distal waves mean amplitude and percentage of pathological waves in patients with non-erosive reflux disease (NERD). • Erosive reflux disease (ERD) parameters were not significantly modified by tDCS. These data strengthen the hypothesis of a different pathophysiology and progression into a chronic (i.e. unresponsive) form in patients with ERD.
ISSN:	1388-2457 1872-8952
DOI:	10.1016/j.clinph.2013.12.110