Hepatoprotective effect of silymarin on di(2-ethylhexyl)phthalate (DEHP) induced injury in liver FL83B cells

Highlights • DEHP, a toxic environmental pollutant, caused liver injury in FL83B cells. • Silymarin could ameliorate DEHP-induced injury. • Silymarin can reduce LDH, ALT and cell population of sub-G1 and S phase. • Silymarin at 25 μM achieved the highest hepatoprotective effect.

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Bibliographische Detailangaben
Veröffentlicht in:	Environmental toxicology and pharmacology 2014-07, Vol.38 (1), p.112-118
Hauptverfasser:	Lo, Diana, Wang, Yuh-Tai, Wu, Ming-Chang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - metabolism Animals Aspartate Aminotransferases - metabolism Cell Cycle - drug effects Cell Line Cell Survival - drug effects Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism Di(2-ethylhexyl)phthalate Diethylhexyl Phthalate - toxicity Emergency Environmental Pollutants - toxicity FL83B cells Hepatoprotective L-Lactate Dehydrogenase - metabolism Liver - cytology Liver injury Mice Plasticizers - toxicity Protective Agents - pharmacology Silymarin Silymarin - pharmacology
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Beschreibung
Zusammenfassung:	Highlights • DEHP, a toxic environmental pollutant, caused liver injury in FL83B cells. • Silymarin could ameliorate DEHP-induced injury. • Silymarin can reduce LDH, ALT and cell population of sub-G1 and S phase. • Silymarin at 25 μM achieved the highest hepatoprotective effect.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2014.05.005