COLLOIDAL DISPERSIONS OF ORDERED LIPID-WATER PHASES

Aqueous dispersions of colloidal aggregates of liquid-crystalline lipid-water phases are described. The lamellar liquid-crystalline phase can form liposomal dispersions, which are wellknown from extensive studies of these particles in drug delivery. Less is known about dispersions of cubic and hexag...

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Veröffentlicht in:	Journal of dispersion science and technology 1999-01, Vol.20 (1-2), p.27-34
1. Verfasser:	Larsson, Kåre
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Conformations Controlled drug delivery Disperse state. Micelles Fundamental and applied biological sciences. Psychology Lipids Liquid crystals Molecular biophysics Physico-chemical properties of biomolecules Water
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Beschreibung
Zusammenfassung:	Aqueous dispersions of colloidal aggregates of liquid-crystalline lipid-water phases are described. The lamellar liquid-crystalline phase can form liposomal dispersions, which are wellknown from extensive studies of these particles in drug delivery. Less is known about dispersions of cubic and hexagonal phases. The preparation of such colloidal dispersions, their structure and physical properties are summerised. The dispersed cubic phase is compared to liposomal dispersions, and it is concluded that an important application of the cubic particles will involve encapsulation of proteins and protection of their native conformation.
ISSN:	0193-2691 1532-2351
DOI:	10.1080/01932699908943777