Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks

A collection of novel, pharmaceutically relevant cubane-containing molecules has been prepared from the commercially available cubane-1,4-dimethylester. A range of synthetic methods have been applied to prepare these cubane building blocks with one or two functional handles to allow easy incorpor...

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Veröffentlicht in:	Organic letters 2014-08, Vol.16 (16), p.4094-4097
Hauptverfasser:	Wlochal, Joanna, Davies, Robert D. M, Burton, Jonathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Bridged-Ring Compounds - chemistry Chemistry, Pharmaceutical Heterocyclic Compounds - chemistry Models, Molecular Molecular Structure
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description	A collection of novel, pharmaceutically relevant cubane-containing molecules has been prepared from the commercially available cubane-1,4-dimethylester. A range of synthetic methods have been applied to prepare these cubane building blocks with one or two functional handles to allow easy incorporation into existing medicinal chemistry programs.
doi_str_mv	10.1021/ol501750k
format	Article
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subjects	Bridged-Ring Compounds - chemistry Chemistry, Pharmaceutical Heterocyclic Compounds - chemistry Models, Molecular Molecular Structure
title	Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks
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