Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks

Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks

A collection of novel, pharma­ceutically relevant cubane-containing molecules has been prepared from the commercially available cubane-1,4-di­methyl­ester. A range of synthetic methods have been applied to prepare these cubane building blocks with one or two functional handles to allow easy incorpor...

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Veröffentlicht in:Organic letters 2014-08, Vol.16 (16), p.4094-4097
Hauptverfasser: Wlochal, Joanna, Davies, Robert D. M, Burton, Jonathan
Format: Artikel
Sprache:eng
Schlagworte:
Bridged-Ring Compounds - chemistry
Chemistry, Pharmaceutical
Heterocyclic Compounds - chemistry
Models, Molecular
Molecular Structure
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Zusammenfassung:A collection of novel, pharma­ceutically relevant cubane-containing molecules has been prepared from the commercially available cubane-1,4-di­methyl­ester. A range of synthetic methods have been applied to prepare these cubane building blocks with one or two functional handles to allow easy incorporation into existing medicinal chemistry programs.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol501750k