Atom-Economical Access to Highly Substituted Indenes and Furan-2-ones via Tandem Reaction of Diazo Compounds and Propargyl Alcohols

Atom-Economical Access to Highly Substituted Indenes and Furan-2-ones via Tandem Reaction of Diazo Compounds and Propargyl Alcohols

A facile synthesis of highly substituted as well as conjugated indene/furanone systems via a BF3·OEt2 catalyzed tandem reaction of α-diazo-esters/-amides and propargyl alcohols has been demonstrated under mild conditions. This method offers great potential for the synthesis of biologically active in...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2014-08, Vol.16 (16), p.4248-4251
Hauptverfasser: Muthusamy, Sengodagounder, Sivaguru, Manickasamy
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes - chemistry
Azo Compounds - chemistry
Catalysis
Cyclization
Furans - chemical synthesis
Furans - chemistry
Indenes - chemical synthesis
Indenes - chemistry
Molecular Structure
Polycyclic Compounds - chemical synthesis
Polycyclic Compounds - chemistry
Propanols - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A facile synthesis of highly substituted as well as conjugated indene/furanone systems via a BF3·OEt2 catalyzed tandem reaction of α-diazo-esters/-amides and propargyl alcohols has been demonstrated under mild conditions. This method offers great potential for the synthesis of biologically active indene and furanone derivatives and their related polycyclic compounds.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol501942y