The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity

Au25 clusters stabilized by tridecapeptides were firstly synthesized, which can well penetrate the cell membrane and exactly locate in the cytoplasm. Hence the Au clusters significantly suppress the TrxR1 activity in the cytoplasm, and further induce the up-regulation of the activated PARP level whi...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2014-09, Vol.50 (73), p.10687-10690
Hauptverfasser:	Liu, Ru, Wang, Yaling, Yuan, Qing, An, Deyi, Li, Jingyuan, Gao, Xueyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Apoptosis - drug effects Enzyme Activation - drug effects Gold - chemistry Gold - pharmacology HeLa Cells Humans Nanoparticles - chemistry Nanoparticles - metabolism Nanoparticles - therapeutic use Oligopeptides - chemistry Particle Size Poly(ADP-ribose) Polymerases - metabolism Protein Binding Protein Structure, Tertiary Reactive Oxygen Species - metabolism Thioredoxin Reductase 1 - antagonists & inhibitors Thioredoxin Reductase 1 - metabolism Up-Regulation
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