The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity

The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity

Au25 clusters stabilized by tridecapeptides were firstly synthesized, which can well penetrate the cell membrane and exactly locate in the cytoplasm. Hence the Au clusters significantly suppress the TrxR1 activity in the cytoplasm, and further induce the up-regulation of the activated PARP level whi...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014-09, Vol.50 (73), p.10687-10690
Hauptverfasser: Liu, Ru, Wang, Yaling, Yuan, Qing, An, Deyi, Li, Jingyuan, Gao, Xueyun
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Apoptosis - drug effects
Enzyme Activation - drug effects
Gold - chemistry
Gold - pharmacology
HeLa Cells
Humans
Nanoparticles - chemistry
Nanoparticles - metabolism
Nanoparticles - therapeutic use
Oligopeptides - chemistry
Particle Size
Poly(ADP-ribose) Polymerases - metabolism
Protein Binding
Protein Structure, Tertiary
Reactive Oxygen Species - metabolism
Thioredoxin Reductase 1 - antagonists & inhibitors
Thioredoxin Reductase 1 - metabolism
Up-Regulation
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Zusammenfassung:Au25 clusters stabilized by tridecapeptides were firstly synthesized, which can well penetrate the cell membrane and exactly locate in the cytoplasm. Hence the Au clusters significantly suppress the TrxR1 activity in the cytoplasm, and further induce the up-regulation of the activated PARP level which allows the tumor cell apoptosis to occur in a Au dose dependent manner.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc03320e