The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity
Au25 clusters stabilized by tridecapeptides were firstly synthesized, which can well penetrate the cell membrane and exactly locate in the cytoplasm. Hence the Au clusters significantly suppress the TrxR1 activity in the cytoplasm, and further induce the up-regulation of the activated PARP level whi...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2014-09, Vol.50 (73), p.10687-10690 |
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| container_issue | 73 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Liu, Ru Wang, Yaling Yuan, Qing An, Deyi Li, Jingyuan Gao, Xueyun |
| description | Au25 clusters stabilized by tridecapeptides were firstly synthesized, which can well penetrate the cell membrane and exactly locate in the cytoplasm. Hence the Au clusters significantly suppress the TrxR1 activity in the cytoplasm, and further induce the up-regulation of the activated PARP level which allows the tumor cell apoptosis to occur in a Au dose dependent manner. |
| doi_str_mv | 10.1039/c4cc03320e |
| format | Article |
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Hence the Au clusters significantly suppress the TrxR1 activity in the cytoplasm, and further induce the up-regulation of the activated PARP level which allows the tumor cell apoptosis to occur in a Au dose dependent manner.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c4cc03320e</identifier><identifier>PMID: 25078326</identifier><language>eng</language><publisher>England</publisher><subject>Amino Acid Sequence ; Apoptosis - drug effects ; Enzyme Activation - drug effects ; Gold - chemistry ; Gold - pharmacology ; HeLa Cells ; Humans ; Nanoparticles - chemistry ; Nanoparticles - metabolism ; Nanoparticles - therapeutic use ; Oligopeptides - chemistry ; Particle Size ; Poly(ADP-ribose) Polymerases - metabolism ; Protein Binding ; Protein Structure, Tertiary ; Reactive Oxygen Species - metabolism ; Thioredoxin Reductase 1 - antagonists & inhibitors ; Thioredoxin Reductase 1 - metabolism ; Up-Regulation</subject><ispartof>Chemical communications (Cambridge, England), 2014-09, Vol.50 (73), p.10687-10690</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-459143731cfd6a9d364308e10a10f908045886a0cdb8b1f76a910c38ca1722d83</citedby><cites>FETCH-LOGICAL-c353t-459143731cfd6a9d364308e10a10f908045886a0cdb8b1f76a910c38ca1722d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25078326$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Ru</creatorcontrib><creatorcontrib>Wang, Yaling</creatorcontrib><creatorcontrib>Yuan, Qing</creatorcontrib><creatorcontrib>An, Deyi</creatorcontrib><creatorcontrib>Li, Jingyuan</creatorcontrib><creatorcontrib>Gao, Xueyun</creatorcontrib><title>The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>Au25 clusters stabilized by tridecapeptides were firstly synthesized, which can well penetrate the cell membrane and exactly locate in the cytoplasm. Hence the Au clusters significantly suppress the TrxR1 activity in the cytoplasm, and further induce the up-regulation of the activated PARP level which allows the tumor cell apoptosis to occur in a Au dose dependent manner.</description><subject>Amino Acid Sequence</subject><subject>Apoptosis - drug effects</subject><subject>Enzyme Activation - drug effects</subject><subject>Gold - chemistry</subject><subject>Gold - pharmacology</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - metabolism</subject><subject>Nanoparticles - therapeutic use</subject><subject>Oligopeptides - chemistry</subject><subject>Particle Size</subject><subject>Poly(ADP-ribose) Polymerases - metabolism</subject><subject>Protein Binding</subject><subject>Protein Structure, Tertiary</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Thioredoxin Reductase 1 - antagonists & inhibitors</subject><subject>Thioredoxin Reductase 1 - metabolism</subject><subject>Up-Regulation</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM9LwzAYhoMobk4v_gGS4xSqSZOs6XGU-QMGgkzwVrI03SJdW_MlYzv7j9u66Xd5v8PDC--D0DUl95Sw9EFzrQljMTEnaEjZhEeCy4_T_hdplDAuBugC4JN0R4U8R4NYkESyeDJE34u1wdOAdRXAGwfY1kXQBvuwaRzWpqqwapvWN2ABb63C0BptS6tVVe2xV25lvK1X2K9t40zR7GyNuwzaKzCY4vHC7d7oLVZ1gSG0rTMAPW89YKW93Vq_v0RnparAXB1zhN4fZ4vsOZq_Pr1k03mkmWA-4iKlnCWM6rKYqLTohjIiDSWKkjIlknAh5UQRXSzlkpZJx1CimdSKJnFcSDZC40Nv65qvYMDnGwv9RFWbJkBOhWAJSYTgHXp3QLVrAJwp89bZjXL7nJK8l55nPMt-pc86-ObYG5YbU_yjf5bZD-l4fb8</recordid><startdate>20140921</startdate><enddate>20140921</enddate><creator>Liu, Ru</creator><creator>Wang, Yaling</creator><creator>Yuan, Qing</creator><creator>An, Deyi</creator><creator>Li, Jingyuan</creator><creator>Gao, Xueyun</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140921</creationdate><title>The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity</title><author>Liu, Ru ; Wang, Yaling ; Yuan, Qing ; An, Deyi ; Li, Jingyuan ; Gao, Xueyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-459143731cfd6a9d364308e10a10f908045886a0cdb8b1f76a910c38ca1722d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Amino Acid Sequence</topic><topic>Apoptosis - drug effects</topic><topic>Enzyme Activation - drug effects</topic><topic>Gold - chemistry</topic><topic>Gold - pharmacology</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - metabolism</topic><topic>Nanoparticles - therapeutic use</topic><topic>Oligopeptides - chemistry</topic><topic>Particle Size</topic><topic>Poly(ADP-ribose) Polymerases - metabolism</topic><topic>Protein Binding</topic><topic>Protein Structure, Tertiary</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Thioredoxin Reductase 1 - antagonists & inhibitors</topic><topic>Thioredoxin Reductase 1 - metabolism</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Ru</creatorcontrib><creatorcontrib>Wang, Yaling</creatorcontrib><creatorcontrib>Yuan, Qing</creatorcontrib><creatorcontrib>An, Deyi</creatorcontrib><creatorcontrib>Li, Jingyuan</creatorcontrib><creatorcontrib>Gao, Xueyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Ru</au><au>Wang, Yaling</au><au>Yuan, Qing</au><au>An, Deyi</au><au>Li, Jingyuan</au><au>Gao, Xueyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2014-09-21</date><risdate>2014</risdate><volume>50</volume><issue>73</issue><spage>10687</spage><epage>10690</epage><pages>10687-10690</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>Au25 clusters stabilized by tridecapeptides were firstly synthesized, which can well penetrate the cell membrane and exactly locate in the cytoplasm. Hence the Au clusters significantly suppress the TrxR1 activity in the cytoplasm, and further induce the up-regulation of the activated PARP level which allows the tumor cell apoptosis to occur in a Au dose dependent manner.</abstract><cop>England</cop><pmid>25078326</pmid><doi>10.1039/c4cc03320e</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2014-09, Vol.50 (73), p.10687-10690 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1553707554 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Apoptosis - drug effects Enzyme Activation - drug effects Gold - chemistry Gold - pharmacology HeLa Cells Humans Nanoparticles - chemistry Nanoparticles - metabolism Nanoparticles - therapeutic use Oligopeptides - chemistry Particle Size Poly(ADP-ribose) Polymerases - metabolism Protein Binding Protein Structure, Tertiary Reactive Oxygen Species - metabolism Thioredoxin Reductase 1 - antagonists & inhibitors Thioredoxin Reductase 1 - metabolism Up-Regulation |
| title | The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity |
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