Dysmotility by mechanical bowel preparation using polyethylene glycol
Abstract Background The effects of mechanical bowel preparation (MBP) on morbidity (e.g., anastomotic leakage and surgical site infection) have been evaluated. Its effect on early recovery after surgery has drawn renewed attention, and its use is discouraged in the postsurgical management of enhance...
Gespeichert in:
| Veröffentlicht in: | The Journal of surgical research 2014-09, Vol.191 (1), p.84-90 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 90 |
|---|---|
| container_issue | 1 |
| container_start_page | 84 |
| container_title | The Journal of surgical research |
| container_volume | 191 |
| creator | Yamada, Takeshi, MD, PhD Kan, Hayato, MD, PhD Matsumoto, Satoshi, MD, PhD Koizumi, Michihiro, MD, PhD Matsuda, Akihisa, MD, PhD Shinji, Seiichi, MD, PhD Sasaki, Junpei, MD, PhD Uchida, Eiji, MD, PhD |
| description | Abstract Background The effects of mechanical bowel preparation (MBP) on morbidity (e.g., anastomotic leakage and surgical site infection) have been evaluated. Its effect on early recovery after surgery has drawn renewed attention, and its use is discouraged in the postsurgical management of enhanced recovery. However, most surgeons in Japan prefer polyethylene glycol (PEG) for MBP. We investigated the effect of MBP with PEG on postoperative intestinal motility. Materials and methods We prospectively evaluated a consecutive series of 258 colon cancer patients who underwent colonic resection and primary anastomosis. We orally administered 2000 mL of PEG in the PEG group and did not administer PEG to patients in the no-PEG group. Postoperative gastrointestinal motility was assessed with radiopaque markers. All patients ingested radiopaque markers 2 h before surgery. Postoperative intestinal motility was radiologically assessed by counting the number of residual markers. Abdominal radiography was conducted on postoperative days 1, 3, and 5 to count residual markers in the large and small intestines. Results The total number of residual markers in the no-PEG group was less than that in the PEG group on day 5 ( P |
| doi_str_mv | 10.1016/j.jss.2014.03.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1553706095</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022480414002352</els_id><sourcerecordid>1553706095</sourcerecordid><originalsourceid>FETCH-LOGICAL-c544t-e28b91c24d406325a8aa0e611f79e11cf4a28f35e5af471858e1f5a905b47dc63</originalsourceid><addsrcrecordid>eNp9kUtv1TAQhS0Eam8LP4ANypJNUo8feQgJCZU-kCqxoF1bjjNpHZw42Emr_Ht8ewsLFqxmRjrnSPMdQt4DLYBCeTYUQ4wFoyAKygtK4RXZAW1kXpcVf012lDKWi5qKY3IS40DT3VT8iBwzUctKCtiRi69bHP1inV22rN2yEc2DnqzRLmv9E7psDjjroBfrp2yNdrrPZu82XB42hxNm924z3r0lb3rtIr57mafk7vLi9vw6v_l-9e38y01upBBLjqxuGzBMdIKWnElda02xBOirBgFMLzSrey5R6l5UUMsaoZe6obIVVWdKfko-HnLn4H-tGBc12mjQOT2hX6MCKXlFy4QgSeEgNcHHGLBXc7CjDpsCqvb01KASPbWnpyhXiV7yfHiJX9sRu7-OP7iS4NNBgOnJR4tBRWNxMtjZgGZRnbf_jf_8j9s4-8z6J24YB7-GKdFToCJTVP3Y17dvD0TauGT8N8_BlOI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1553706095</pqid></control><display><type>article</type><title>Dysmotility by mechanical bowel preparation using polyethylene glycol</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Yamada, Takeshi, MD, PhD ; Kan, Hayato, MD, PhD ; Matsumoto, Satoshi, MD, PhD ; Koizumi, Michihiro, MD, PhD ; Matsuda, Akihisa, MD, PhD ; Shinji, Seiichi, MD, PhD ; Sasaki, Junpei, MD, PhD ; Uchida, Eiji, MD, PhD</creator><creatorcontrib>Yamada, Takeshi, MD, PhD ; Kan, Hayato, MD, PhD ; Matsumoto, Satoshi, MD, PhD ; Koizumi, Michihiro, MD, PhD ; Matsuda, Akihisa, MD, PhD ; Shinji, Seiichi, MD, PhD ; Sasaki, Junpei, MD, PhD ; Uchida, Eiji, MD, PhD</creatorcontrib><description>Abstract Background The effects of mechanical bowel preparation (MBP) on morbidity (e.g., anastomotic leakage and surgical site infection) have been evaluated. Its effect on early recovery after surgery has drawn renewed attention, and its use is discouraged in the postsurgical management of enhanced recovery. However, most surgeons in Japan prefer polyethylene glycol (PEG) for MBP. We investigated the effect of MBP with PEG on postoperative intestinal motility. Materials and methods We prospectively evaluated a consecutive series of 258 colon cancer patients who underwent colonic resection and primary anastomosis. We orally administered 2000 mL of PEG in the PEG group and did not administer PEG to patients in the no-PEG group. Postoperative gastrointestinal motility was assessed with radiopaque markers. All patients ingested radiopaque markers 2 h before surgery. Postoperative intestinal motility was radiologically assessed by counting the number of residual markers. Abdominal radiography was conducted on postoperative days 1, 3, and 5 to count residual markers in the large and small intestines. Results The total number of residual markers in the no-PEG group was less than that in the PEG group on day 5 ( P < 0.01) but not on days 1 and 3. On all 3 d, the numbers of residual markers in the small intestine were significantly less in the no-PEG group than in the PEG group ( P < 0.001). There were no differences in postoperative complications between the no-PEG and PEG groups. Conclusions PEG can negatively affect postoperative intestinal motility, and MBP using PEG is unnecessary in elective colon cancer surgery.</description><identifier>ISSN: 0022-4804</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1016/j.jss.2014.03.001</identifier><identifier>PMID: 24857541</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anastomotic Leak - prevention & control ; Colectomy - adverse effects ; Colon cancer ; Colonic Neoplasms - surgery ; Colostomy - adverse effects ; Elective Surgical Procedures - adverse effects ; Enhanced recovery after surgery (ERAS) ; Female ; Gastrointestinal Motility - drug effects ; Humans ; Male ; Mechanical bowel preparation (MBP) ; Middle Aged ; Polyethylene glycol ; Polyethylene Glycols - therapeutic use ; Preoperative Care - methods ; Prospective Studies ; Recovery of Function ; Surface-Active Agents - therapeutic use ; Surgery ; Surgical Wound Infection - prevention & control ; Young Adult</subject><ispartof>The Journal of surgical research, 2014-09, Vol.191 (1), p.84-90</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c544t-e28b91c24d406325a8aa0e611f79e11cf4a28f35e5af471858e1f5a905b47dc63</citedby><cites>FETCH-LOGICAL-c544t-e28b91c24d406325a8aa0e611f79e11cf4a28f35e5af471858e1f5a905b47dc63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jss.2014.03.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24857541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamada, Takeshi, MD, PhD</creatorcontrib><creatorcontrib>Kan, Hayato, MD, PhD</creatorcontrib><creatorcontrib>Matsumoto, Satoshi, MD, PhD</creatorcontrib><creatorcontrib>Koizumi, Michihiro, MD, PhD</creatorcontrib><creatorcontrib>Matsuda, Akihisa, MD, PhD</creatorcontrib><creatorcontrib>Shinji, Seiichi, MD, PhD</creatorcontrib><creatorcontrib>Sasaki, Junpei, MD, PhD</creatorcontrib><creatorcontrib>Uchida, Eiji, MD, PhD</creatorcontrib><title>Dysmotility by mechanical bowel preparation using polyethylene glycol</title><title>The Journal of surgical research</title><addtitle>J Surg Res</addtitle><description>Abstract Background The effects of mechanical bowel preparation (MBP) on morbidity (e.g., anastomotic leakage and surgical site infection) have been evaluated. Its effect on early recovery after surgery has drawn renewed attention, and its use is discouraged in the postsurgical management of enhanced recovery. However, most surgeons in Japan prefer polyethylene glycol (PEG) for MBP. We investigated the effect of MBP with PEG on postoperative intestinal motility. Materials and methods We prospectively evaluated a consecutive series of 258 colon cancer patients who underwent colonic resection and primary anastomosis. We orally administered 2000 mL of PEG in the PEG group and did not administer PEG to patients in the no-PEG group. Postoperative gastrointestinal motility was assessed with radiopaque markers. All patients ingested radiopaque markers 2 h before surgery. Postoperative intestinal motility was radiologically assessed by counting the number of residual markers. Abdominal radiography was conducted on postoperative days 1, 3, and 5 to count residual markers in the large and small intestines. Results The total number of residual markers in the no-PEG group was less than that in the PEG group on day 5 ( P < 0.01) but not on days 1 and 3. On all 3 d, the numbers of residual markers in the small intestine were significantly less in the no-PEG group than in the PEG group ( P < 0.001). There were no differences in postoperative complications between the no-PEG and PEG groups. Conclusions PEG can negatively affect postoperative intestinal motility, and MBP using PEG is unnecessary in elective colon cancer surgery.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anastomotic Leak - prevention & control</subject><subject>Colectomy - adverse effects</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - surgery</subject><subject>Colostomy - adverse effects</subject><subject>Elective Surgical Procedures - adverse effects</subject><subject>Enhanced recovery after surgery (ERAS)</subject><subject>Female</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Mechanical bowel preparation (MBP)</subject><subject>Middle Aged</subject><subject>Polyethylene glycol</subject><subject>Polyethylene Glycols - therapeutic use</subject><subject>Preoperative Care - methods</subject><subject>Prospective Studies</subject><subject>Recovery of Function</subject><subject>Surface-Active Agents - therapeutic use</subject><subject>Surgery</subject><subject>Surgical Wound Infection - prevention & control</subject><subject>Young Adult</subject><issn>0022-4804</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1TAQhS0Eam8LP4ANypJNUo8feQgJCZU-kCqxoF1bjjNpHZw42Emr_Ht8ewsLFqxmRjrnSPMdQt4DLYBCeTYUQ4wFoyAKygtK4RXZAW1kXpcVf012lDKWi5qKY3IS40DT3VT8iBwzUctKCtiRi69bHP1inV22rN2yEc2DnqzRLmv9E7psDjjroBfrp2yNdrrPZu82XB42hxNm924z3r0lb3rtIr57mafk7vLi9vw6v_l-9e38y01upBBLjqxuGzBMdIKWnElda02xBOirBgFMLzSrey5R6l5UUMsaoZe6obIVVWdKfko-HnLn4H-tGBc12mjQOT2hX6MCKXlFy4QgSeEgNcHHGLBXc7CjDpsCqvb01KASPbWnpyhXiV7yfHiJX9sRu7-OP7iS4NNBgOnJR4tBRWNxMtjZgGZRnbf_jf_8j9s4-8z6J24YB7-GKdFToCJTVP3Y17dvD0TauGT8N8_BlOI</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Yamada, Takeshi, MD, PhD</creator><creator>Kan, Hayato, MD, PhD</creator><creator>Matsumoto, Satoshi, MD, PhD</creator><creator>Koizumi, Michihiro, MD, PhD</creator><creator>Matsuda, Akihisa, MD, PhD</creator><creator>Shinji, Seiichi, MD, PhD</creator><creator>Sasaki, Junpei, MD, PhD</creator><creator>Uchida, Eiji, MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>Dysmotility by mechanical bowel preparation using polyethylene glycol</title><author>Yamada, Takeshi, MD, PhD ; Kan, Hayato, MD, PhD ; Matsumoto, Satoshi, MD, PhD ; Koizumi, Michihiro, MD, PhD ; Matsuda, Akihisa, MD, PhD ; Shinji, Seiichi, MD, PhD ; Sasaki, Junpei, MD, PhD ; Uchida, Eiji, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c544t-e28b91c24d406325a8aa0e611f79e11cf4a28f35e5af471858e1f5a905b47dc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anastomotic Leak - prevention & control</topic><topic>Colectomy - adverse effects</topic><topic>Colon cancer</topic><topic>Colonic Neoplasms - surgery</topic><topic>Colostomy - adverse effects</topic><topic>Elective Surgical Procedures - adverse effects</topic><topic>Enhanced recovery after surgery (ERAS)</topic><topic>Female</topic><topic>Gastrointestinal Motility - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Mechanical bowel preparation (MBP)</topic><topic>Middle Aged</topic><topic>Polyethylene glycol</topic><topic>Polyethylene Glycols - therapeutic use</topic><topic>Preoperative Care - methods</topic><topic>Prospective Studies</topic><topic>Recovery of Function</topic><topic>Surface-Active Agents - therapeutic use</topic><topic>Surgery</topic><topic>Surgical Wound Infection - prevention & control</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada, Takeshi, MD, PhD</creatorcontrib><creatorcontrib>Kan, Hayato, MD, PhD</creatorcontrib><creatorcontrib>Matsumoto, Satoshi, MD, PhD</creatorcontrib><creatorcontrib>Koizumi, Michihiro, MD, PhD</creatorcontrib><creatorcontrib>Matsuda, Akihisa, MD, PhD</creatorcontrib><creatorcontrib>Shinji, Seiichi, MD, PhD</creatorcontrib><creatorcontrib>Sasaki, Junpei, MD, PhD</creatorcontrib><creatorcontrib>Uchida, Eiji, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada, Takeshi, MD, PhD</au><au>Kan, Hayato, MD, PhD</au><au>Matsumoto, Satoshi, MD, PhD</au><au>Koizumi, Michihiro, MD, PhD</au><au>Matsuda, Akihisa, MD, PhD</au><au>Shinji, Seiichi, MD, PhD</au><au>Sasaki, Junpei, MD, PhD</au><au>Uchida, Eiji, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dysmotility by mechanical bowel preparation using polyethylene glycol</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>191</volume><issue>1</issue><spage>84</spage><epage>90</epage><pages>84-90</pages><issn>0022-4804</issn><eissn>1095-8673</eissn><abstract>Abstract Background The effects of mechanical bowel preparation (MBP) on morbidity (e.g., anastomotic leakage and surgical site infection) have been evaluated. Its effect on early recovery after surgery has drawn renewed attention, and its use is discouraged in the postsurgical management of enhanced recovery. However, most surgeons in Japan prefer polyethylene glycol (PEG) for MBP. We investigated the effect of MBP with PEG on postoperative intestinal motility. Materials and methods We prospectively evaluated a consecutive series of 258 colon cancer patients who underwent colonic resection and primary anastomosis. We orally administered 2000 mL of PEG in the PEG group and did not administer PEG to patients in the no-PEG group. Postoperative gastrointestinal motility was assessed with radiopaque markers. All patients ingested radiopaque markers 2 h before surgery. Postoperative intestinal motility was radiologically assessed by counting the number of residual markers. Abdominal radiography was conducted on postoperative days 1, 3, and 5 to count residual markers in the large and small intestines. Results The total number of residual markers in the no-PEG group was less than that in the PEG group on day 5 ( P < 0.01) but not on days 1 and 3. On all 3 d, the numbers of residual markers in the small intestine were significantly less in the no-PEG group than in the PEG group ( P < 0.001). There were no differences in postoperative complications between the no-PEG and PEG groups. Conclusions PEG can negatively affect postoperative intestinal motility, and MBP using PEG is unnecessary in elective colon cancer surgery.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24857541</pmid><doi>10.1016/j.jss.2014.03.001</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-4804 |
| ispartof | The Journal of surgical research, 2014-09, Vol.191 (1), p.84-90 |
| issn | 0022-4804 1095-8673 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1553706095 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Aged Aged, 80 and over Anastomotic Leak - prevention & control Colectomy - adverse effects Colon cancer Colonic Neoplasms - surgery Colostomy - adverse effects Elective Surgical Procedures - adverse effects Enhanced recovery after surgery (ERAS) Female Gastrointestinal Motility - drug effects Humans Male Mechanical bowel preparation (MBP) Middle Aged Polyethylene glycol Polyethylene Glycols - therapeutic use Preoperative Care - methods Prospective Studies Recovery of Function Surface-Active Agents - therapeutic use Surgery Surgical Wound Infection - prevention & control Young Adult |
| title | Dysmotility by mechanical bowel preparation using polyethylene glycol |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T17%3A05%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dysmotility%20by%20mechanical%20bowel%20preparation%20using%20polyethylene%20glycol&rft.jtitle=The%20Journal%20of%20surgical%20research&rft.au=Yamada,%20Takeshi,%20MD,%20PhD&rft.date=2014-09-01&rft.volume=191&rft.issue=1&rft.spage=84&rft.epage=90&rft.pages=84-90&rft.issn=0022-4804&rft.eissn=1095-8673&rft_id=info:doi/10.1016/j.jss.2014.03.001&rft_dat=%3Cproquest_cross%3E1553706095%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1553706095&rft_id=info:pmid/24857541&rft_els_id=S0022480414002352&rfr_iscdi=true |