Progranulin in neurodegenerative disease

Progranulin in neurodegenerative disease

Highlights • Frontotemporal dementia (FTD) caused by progranulin mutations is clinically heterogeneous. • Genetic variation in progranulin is linked to multiple neurodegenerative disorders. • Progranulin is a pleiotropic protein and plays diverse roles in the brain. • Recent evidence implicates a ro...

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Veröffentlicht in:Trends in neurosciences (Regular ed.) 2014-07, Vol.37 (7), p.388-398
Hauptverfasser: Petkau, Terri L, Leavitt, Blair R
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Brain
Brain - metabolism
Brain - pathology
Dementia
Genetic Variation - genetics
Genotype & phenotype
Humans
Intercellular Signaling Peptides and Proteins - genetics
Mice
Mutation
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - pathology
Neurology
Neurons - metabolism
Neurons - pathology
Neurosciences
Rodents
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Beschreibung
Zusammenfassung:Highlights • Frontotemporal dementia (FTD) caused by progranulin mutations is clinically heterogeneous. • Genetic variation in progranulin is linked to multiple neurodegenerative disorders. • Progranulin is a pleiotropic protein and plays diverse roles in the brain. • Recent evidence implicates a role for progranulin in lysosome function.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2014.04.003