HLA-Cw polypmorphism and killer cell immunoglobulin-like receptor (KIR) gene analysis in Korean colorectal cancer patients

HLA-Cw polypmorphism and killer cell immunoglobulin-like receptor (KIR) gene analysis in Korean colorectal cancer patients

Abstract Purpose Natural killer cells (NK cells) play important roles in protecting the patient from the early development of cancers, and are activated or inhibited by killer cell immunoglobulin-like receptors (KIR), which bind to HLA class I. In the present study, we investigated the KIR genotype...

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Veröffentlicht in:International journal of surgery (London, England) England), 2014-01, Vol.12 (8), p.815-820
Hauptverfasser: Kim, Hyung-Jin, Choi, Hae-Baeg, Jang, Jung-Pil, Baek, In-Cheol, Choi, Eun-Jeong, Park, Miyoung, Kim, Tai-Gyu, Oh, Seong-Taek
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Case-Control Studies
Colonic Neoplasms - genetics
Colonic Neoplasms - immunology
Colorectal cancer
Female
Genotype
HLA-C Antigens - analysis
HLA-C Antigens - genetics
HLA-Cw
Humans
Killer Cells, Natural - chemistry
KIR
Male
Middle Aged
NK cells
Polymorphism, Genetic
Receptors, KIR - analysis
Receptors, KIR - genetics
Rectal Neoplasms - genetics
Rectal Neoplasms - immunology
Republic of Korea
Surgery
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Zusammenfassung:Abstract Purpose Natural killer cells (NK cells) play important roles in protecting the patient from the early development of cancers, and are activated or inhibited by killer cell immunoglobulin-like receptors (KIR), which bind to HLA class I. In the present study, we investigated the KIR genotype of Korean colorectal cancer patients. Methods DNA samples were extracted from peripheral blood cell samples taken from Korean colorectal cancer patients and a control group. KIR genes were amplified using PCR-SSP methods, and HLA-Cw genes were characterized using PCR methods. The results were analyzed to assess the difference between colorectal cancer patients and the normal control group. Results In the present study, the frequency of KIR2DS5 (33.2% vs. 20.8%, p -value 
ISSN:1743-9191
1743-9159
DOI:10.1016/j.ijsu.2014.06.012