Dramatic lowering of very high Lp(a) in response to niacin

Abstract We describe a patient with markedly elevated lipoprotein(a) (Lp(a)) without any other lipid abnormalities. After a myocardial infarction, she was treated with combination of extended-release niacin and statin. An 88% reduction in Lp(a) was observed during 5 years of treatment, which is much...

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Veröffentlicht in:	Journal of clinical lipidology 2014-07, Vol.8 (4), p.448-450
Hauptverfasser:	Li, Min, MD, PhD, Saeedi, Ramesh, MD, PhD, Rabkin, Simon W., MD, Frohlich, Jiri, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Atorvastatin Calcium Biomarkers - metabolism Cardiovascular Coronary artery disease (CAD) Coronary Artery Disease - complications Coronary Artery Disease - diagnosis Coronary Artery Disease - drug therapy Disease-Free Survival Female Heptanoic Acids - therapeutic use Humans Hypolipidemic Agents - therapeutic use Lipoprotein(a) - metabolism Lipoprotein(a) [Lp(a)] Middle Aged Myocardial Infarction - diagnosis Myocardial Infarction - drug therapy Myocardial Infarction - etiology Niacin Niacin - therapeutic use Pyrroles - therapeutic use Risk Statin
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Zusammenfassung:	Abstract We describe a patient with markedly elevated lipoprotein(a) (Lp(a)) without any other lipid abnormalities. After a myocardial infarction, she was treated with combination of extended-release niacin and statin. An 88% reduction in Lp(a) was observed during 5 years of treatment, which is much better response than usually reported.
ISSN:	1933-2874 1876-4789
DOI:	10.1016/j.jacl.2014.03.006