Long-term PT-INR levels and the clinical events in the patients with non-valvular atrial fibrillation: A special reference to low-intensity warfarin therapy

Abstract Background Anticoagulation therapy is essential in atrial fibrillation (AF), and in Japan, less intense control is popular. Purpose To assess the efficacy and safety with a special reference to low intensity warfarin therapy. Subjects and methods In 488 out of 508 patients with non-valvular...

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Veröffentlicht in:	Journal of cardiology 2014-08, Vol.64 (2), p.127-132
Hauptverfasser:	Takarada, Ken, MD, Sato, Masahito, MD, Goto, Masayuki, MD, Saito, Atsushi, MD, Ikeda, Yoshio, MD, Fujita, Satoru, MD, Fuse, Koichi, MD, Takahashi, Minoru, MD, Oguro, Takeo, MD, Matsushita, Hirooki, MD, Kitazawa, Hitoshi, MD, Okabe, Masaaki, MD, Abe, Hiroshi, MD, Toba, Ken, MD, Yamashina, Akira, MD, FJCC, Aizawa, Yoshifusa, MD, FJCC
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Aged, 80 and over Anticoagulants Anticoagulants - administration & dosage Anticoagulants - adverse effects Atrial fibrillation Atrial Fibrillation - blood Atrial Fibrillation - complications Atrial Fibrillation - drug therapy Cardiovascular Cerebral Hemorrhage - epidemiology Cerebral Hemorrhage - etiology Drug Therapy, Combination Embolism - epidemiology Embolism - etiology Female Follow-Up Studies Head Injuries, Closed Humans International Normalized Ratio Male Middle Aged Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - adverse effects Prothrombin Time Retrospective Studies Risk Sex Factors Stroke Stroke - epidemiology Stroke - etiology Time Factors Warfarin Warfarin - administration & dosage Warfarin - adverse effects
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Zusammenfassung:	Abstract Background Anticoagulation therapy is essential in atrial fibrillation (AF), and in Japan, less intense control is popular. Purpose To assess the efficacy and safety with a special reference to low intensity warfarin therapy. Subjects and methods In 488 out of 508 patients with non-valvular AF, prothrombin time-international normalized ratio (PT-INR) was kept at 1.6–2.59, and they were followed for 49.5 months: 2098 person-years. The mean age was 73.7 ± 9.9 years and 62% were male. The patients were divided by age: ≥70 years and
ISSN:	0914-5087 1876-4738
DOI:	10.1016/j.jjcc.2013.11.015