Solid-Phase Synthesis of Trisubstituted 2,5-Dihydrobenzo[f][1,2,5]thiadiazepine 1,1-Dioxide Derivatives

Solid-Phase Synthesis of Trisubstituted 2,5-Dihydrobenzo[f][1,2,5]thiadiazepine 1,1-Dioxide Derivatives

The solid-phase synthesis of trisubstituted 2,5-dihydrobenzo­[f]­[1,2,5]­thiadiazepine 1,1-dioxides is reported. Acyclic polymer-supported intermediates were prepared using commercially available building blocks: Fmoc-protected amino acids, 2-nitrobenzenesulfonyl chlorides, and bromoketones. The acy...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:ACS combinatorial science 2014-08, Vol.16 (8), p.412-420
Hauptverfasser: Fülöpová, Veronika, Krchňák, Viktor
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acids - chemistry
Benzene Derivatives - chemical synthesis
Benzene Derivatives - chemistry
Chlorides - chemistry
Cyclization
Fluorenes - chemistry
Halogenation
Ketones - chemistry
Nitrobenzenes - chemistry
Oxides - chemical synthesis
Oxides - chemistry
Solid-Phase Synthesis Techniques - methods
Thiazepines - chemical synthesis
Thiazepines - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The solid-phase synthesis of trisubstituted 2,5-dihydrobenzo­[f]­[1,2,5]­thiadiazepine 1,1-dioxides is reported. Acyclic polymer-supported intermediates were prepared using commercially available building blocks: Fmoc-protected amino acids, 2-nitrobenzenesulfonyl chlorides, and bromoketones. The acyclic precursors underwent acid-mediated release from the resin and the cyclization was completed in solution.
ISSN:2156-8952
2156-8944
DOI:10.1021/co500084k