Peculiarities of a large bowel microstructure in children, suffering chronic constipation, caused by its inborn anomaly

Layer-by-layer electron microscopy investigation of the large bowel microstructure in children, suffering chronic constipation (CHC), caused by inborn anomaly (dolichosigma), was conducted. There were investigated 20 intraoperative specimens of the sigmoid colon intestine. Essential changes in all layers of the large bowel were noted. For example, in CHC in decompensated stage there were characteristic features: changes in mucosal epithelium, inhibition of the goblet cells secretion activity, oedema of lamina propria and submucosal layer, the filamental structures disorders. The gut layers trophic function was disordered by the blood vessels and the hemocapillars wall damage. Destructive changes in the smooth myocytes in muscular layer reflects disorder of the organ contractile function. Destructive changes in the large bowel structure are accompanied by the lymph nodes hyperemia, diffuse leukocytic infiltration, witnessing reaction of lymphoid tissue on pathological changes in the organ. Peculiarities of the CHC clinical course, the dolichosigma staging in children were caused by morphological changes of the large bowel wall. The revealed structural reorganization of the gut wall may be considered as a "critical cusative agents", in which propulsive function of sigmoid colonic intestine is inhibited significantly and do not provide an adequate passage of a large bowel contents.