Antineoplastic effect of calycosin on osteosarcoma through inducing apoptosis showing in vitro and in vivo investigations

Recently, increasing studies have documented that tumorigenesis closely relates to apoptotic processes. Thus, inducing apoptosis is an anti-cancer strategy against osteosarcoma. Here we investigated the anti-proliferative effect of calycosin on human osteosarcoma cell (143B) in vitro. The results sh...

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Veröffentlicht in:	Experimental and molecular pathology 2014-08, Vol.97 (1), p.17-22
Hauptverfasser:	Qiu, Rubiao, Ma, Gang, Zheng, Chenguang, Qiu, Xiaoxia, Li, Xinning, Li, Xueyu, Mo, Jianlan, Li, Zhengzhao, Liu, Yun, Mo, Linjian, Bi, Guan, Ye, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Apoptotic Protease-Activating Factor 1 - metabolism Body Weight - drug effects Bone Neoplasms - drug therapy Bone Neoplasms - genetics Bone Neoplasms - pathology Calycosin Caspase 3 - metabolism Cell Line, Tumor - drug effects Cell Proliferation - drug effects Down-Regulation - drug effects Gene Expression Regulation, Neoplastic - drug effects Humans Isoflavones - pharmacology Mice Mice, Inbred BALB C Mice, Nude NF-kappa B - metabolism Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - genetics Osteosarcoma - pathology Proliferation Proto-Oncogene Proteins c-bcl-2 - metabolism Xenograft Model Antitumor Assays
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Zusammenfassung:	Recently, increasing studies have documented that tumorigenesis closely relates to apoptotic processes. Thus, inducing apoptosis is an anti-cancer strategy against osteosarcoma. Here we investigated the anti-proliferative effect of calycosin on human osteosarcoma cell (143B) in vitro. The results showed that calycosin dose-dependently inhibited 143B cell proliferation as reflected in tetrazolium salt (MTT) assay (P
ISSN:	0014-4800 1096-0945
DOI:	10.1016/j.yexmp.2014.04.014