Monocyte count/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease
Background and aim Previous studies showed that renal dysfunction was associated with both a reduction in serum high-density lipoprotein (HDL) cholesterol concentration and increased circulating monocyte count. We aimed to investigate the effect of circulating monocyte to serum HDL cholesterol ratio...
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| Veröffentlicht in: | International urology and nephrology 2014-08, Vol.46 (8), p.1619-1625 |
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| container_title | International urology and nephrology |
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| creator | Kanbay, Mehmet Solak, Yalcin Unal, Hilmi Umut Kurt, Yasemin Gulcan Gok, Mahmut Cetinkaya, Hakki Karaman, Murat Oguz, Yusuf Eyileten, Tayfun Vural, Abdulgaffar Covic, Adrian Goldsmith, David Turak, Osman Yilmaz, Mahmut Ilker |
| description | Background and aim
Previous studies showed that renal dysfunction was associated with both a reduction in serum high-density lipoprotein (HDL) cholesterol concentration and increased circulating monocyte count. We aimed to investigate the effect of circulating monocyte to serum HDL cholesterol ratio (M/H ratio) on fatal and composite cardiovascular events, in an observational cohort study of chronic kidney disease (CKD) patients.
Materials and methods
A total of 340 subjects with stage 1–5 CKD were followed for a mean follow-up period of 33 (range 2–44) months and assessed for fatal and nonfatal CV events. M/H ratio was calculated for all patients. All-cause mortality and CVE were also analyzed in relation to M/H ratio.
Results
Monocyte/HDL cholesterol ratio was negatively correlated with estimated glomerular filtration rate (eGFR) (
r
= −0.43,
P
|
| doi_str_mv | 10.1007/s11255-014-0730-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1552371307</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1552371307</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-f21c93b7f8e7be11483053f9a8ccfbaaf5d9ad9a509cf7c7278e7d69fe82cade3</originalsourceid><addsrcrecordid>eNp1kU9rGzEQxUVpSFw3H6CXIuill01mpFW0eyzpnxQcemnPQtaOGqVryZV2U_ztI8dpKYGAYAT6vTeaeYy9QThDAH1eEIVSDWDbgJbQ4Au2QKVlI1TXvmQLkIANXgh5wl6VcgsAfQdwzE5E2ynZ992C-esUk9tNxF2a43R-9XHF3U0aqUyU08iznULiNg7c2TyEdGeLm0ebOd1RnAoPkW8r8nD_E6abKs4pBsd_hSHSjg-hkC30mh15OxY6faxL9uPzp--XV83q25evlx9WjWtbMTVeoOvlWvuO9JoQ206Ckr63nXN-ba1XQ2_rUdA7r50WuoLDRe-pE84OJJfs_cF3m9PvuQ5hNqE4GkcbKc3FoFJCapR1XUv27gl6m-Yc6-8eKFSg1J7CA-VyKiWTN9scNjbvDILZh2AOIZgagtmHYLBq3j46z-sNDf8Uf7deAXEASn2KPyn_1_pZ13sCbJOR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1552150557</pqid></control><display><type>article</type><title>Monocyte count/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kanbay, Mehmet ; Solak, Yalcin ; Unal, Hilmi Umut ; Kurt, Yasemin Gulcan ; Gok, Mahmut ; Cetinkaya, Hakki ; Karaman, Murat ; Oguz, Yusuf ; Eyileten, Tayfun ; Vural, Abdulgaffar ; Covic, Adrian ; Goldsmith, David ; Turak, Osman ; Yilmaz, Mahmut Ilker</creator><creatorcontrib>Kanbay, Mehmet ; Solak, Yalcin ; Unal, Hilmi Umut ; Kurt, Yasemin Gulcan ; Gok, Mahmut ; Cetinkaya, Hakki ; Karaman, Murat ; Oguz, Yusuf ; Eyileten, Tayfun ; Vural, Abdulgaffar ; Covic, Adrian ; Goldsmith, David ; Turak, Osman ; Yilmaz, Mahmut Ilker</creatorcontrib><description>Background and aim
Previous studies showed that renal dysfunction was associated with both a reduction in serum high-density lipoprotein (HDL) cholesterol concentration and increased circulating monocyte count. We aimed to investigate the effect of circulating monocyte to serum HDL cholesterol ratio (M/H ratio) on fatal and composite cardiovascular events, in an observational cohort study of chronic kidney disease (CKD) patients.
Materials and methods
A total of 340 subjects with stage 1–5 CKD were followed for a mean follow-up period of 33 (range 2–44) months and assessed for fatal and nonfatal CV events. M/H ratio was calculated for all patients. All-cause mortality and CVE were also analyzed in relation to M/H ratio.
Results
Monocyte/HDL cholesterol ratio was negatively correlated with estimated glomerular filtration rate (eGFR) (
r
= −0.43,
P
< 0.001). Notably, both fatal and combined fatal and nonfatal cardiovascular events were more common in patients having a M/H ratio in the third tertile was associated with a hazard ratio of 2.24 and 4.91, respectively, for fatal and composite cardiovascular events compared to being in the first tertile.
Conclusion
Monocyte/HDL cholesterol ratio was increased with decreasing eGFR in predialytic CKD patients. Most importantly, we report for the first time that an increased M/H ratio was cross-sectionally associated with a worse cardiovascular profile and arose as independent predictors of major cardiovascular events during follow-up.</description><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-014-0730-1</identifier><identifier>PMID: 24853998</identifier><identifier>CODEN: IURNAE</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Aged ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - mortality ; Cholesterol, HDL - blood ; Cross-Sectional Studies ; Female ; Glomerular Filtration Rate ; Humans ; Kaplan-Meier Estimate ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - complications ; Leukocyte Count ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Monocytes ; Myocardial Infarction - blood ; Myocardial Infarction - epidemiology ; Nephrology ; Nephrology - Original Paper ; Prospective Studies ; Stroke - blood ; Stroke - epidemiology ; Urology</subject><ispartof>International urology and nephrology, 2014-08, Vol.46 (8), p.1619-1625</ispartof><rights>Springer Science+Business Media Dordrecht 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-f21c93b7f8e7be11483053f9a8ccfbaaf5d9ad9a509cf7c7278e7d69fe82cade3</citedby><cites>FETCH-LOGICAL-c442t-f21c93b7f8e7be11483053f9a8ccfbaaf5d9ad9a509cf7c7278e7d69fe82cade3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-014-0730-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-014-0730-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24853998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kanbay, Mehmet</creatorcontrib><creatorcontrib>Solak, Yalcin</creatorcontrib><creatorcontrib>Unal, Hilmi Umut</creatorcontrib><creatorcontrib>Kurt, Yasemin Gulcan</creatorcontrib><creatorcontrib>Gok, Mahmut</creatorcontrib><creatorcontrib>Cetinkaya, Hakki</creatorcontrib><creatorcontrib>Karaman, Murat</creatorcontrib><creatorcontrib>Oguz, Yusuf</creatorcontrib><creatorcontrib>Eyileten, Tayfun</creatorcontrib><creatorcontrib>Vural, Abdulgaffar</creatorcontrib><creatorcontrib>Covic, Adrian</creatorcontrib><creatorcontrib>Goldsmith, David</creatorcontrib><creatorcontrib>Turak, Osman</creatorcontrib><creatorcontrib>Yilmaz, Mahmut Ilker</creatorcontrib><title>Monocyte count/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Background and aim
Previous studies showed that renal dysfunction was associated with both a reduction in serum high-density lipoprotein (HDL) cholesterol concentration and increased circulating monocyte count. We aimed to investigate the effect of circulating monocyte to serum HDL cholesterol ratio (M/H ratio) on fatal and composite cardiovascular events, in an observational cohort study of chronic kidney disease (CKD) patients.
Materials and methods
A total of 340 subjects with stage 1–5 CKD were followed for a mean follow-up period of 33 (range 2–44) months and assessed for fatal and nonfatal CV events. M/H ratio was calculated for all patients. All-cause mortality and CVE were also analyzed in relation to M/H ratio.
Results
Monocyte/HDL cholesterol ratio was negatively correlated with estimated glomerular filtration rate (eGFR) (
r
= −0.43,
P
< 0.001). Notably, both fatal and combined fatal and nonfatal cardiovascular events were more common in patients having a M/H ratio in the third tertile was associated with a hazard ratio of 2.24 and 4.91, respectively, for fatal and composite cardiovascular events compared to being in the first tertile.
Conclusion
Monocyte/HDL cholesterol ratio was increased with decreasing eGFR in predialytic CKD patients. Most importantly, we report for the first time that an increased M/H ratio was cross-sectionally associated with a worse cardiovascular profile and arose as independent predictors of major cardiovascular events during follow-up.</description><subject>Adult</subject><subject>Aged</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Cholesterol, HDL - blood</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Monocytes</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Nephrology</subject><subject>Nephrology - Original Paper</subject><subject>Prospective Studies</subject><subject>Stroke - blood</subject><subject>Stroke - epidemiology</subject><subject>Urology</subject><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU9rGzEQxUVpSFw3H6CXIuill01mpFW0eyzpnxQcemnPQtaOGqVryZV2U_ztI8dpKYGAYAT6vTeaeYy9QThDAH1eEIVSDWDbgJbQ4Au2QKVlI1TXvmQLkIANXgh5wl6VcgsAfQdwzE5E2ynZ992C-esUk9tNxF2a43R-9XHF3U0aqUyU08iznULiNg7c2TyEdGeLm0ebOd1RnAoPkW8r8nD_E6abKs4pBsd_hSHSjg-hkC30mh15OxY6faxL9uPzp--XV83q25evlx9WjWtbMTVeoOvlWvuO9JoQ206Ckr63nXN-ba1XQ2_rUdA7r50WuoLDRe-pE84OJJfs_cF3m9PvuQ5hNqE4GkcbKc3FoFJCapR1XUv27gl6m-Yc6-8eKFSg1J7CA-VyKiWTN9scNjbvDILZh2AOIZgagtmHYLBq3j46z-sNDf8Uf7deAXEASn2KPyn_1_pZ13sCbJOR</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Kanbay, Mehmet</creator><creator>Solak, Yalcin</creator><creator>Unal, Hilmi Umut</creator><creator>Kurt, Yasemin Gulcan</creator><creator>Gok, Mahmut</creator><creator>Cetinkaya, Hakki</creator><creator>Karaman, Murat</creator><creator>Oguz, Yusuf</creator><creator>Eyileten, Tayfun</creator><creator>Vural, Abdulgaffar</creator><creator>Covic, Adrian</creator><creator>Goldsmith, David</creator><creator>Turak, Osman</creator><creator>Yilmaz, Mahmut Ilker</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140801</creationdate><title>Monocyte count/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease</title><author>Kanbay, Mehmet ; 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Previous studies showed that renal dysfunction was associated with both a reduction in serum high-density lipoprotein (HDL) cholesterol concentration and increased circulating monocyte count. We aimed to investigate the effect of circulating monocyte to serum HDL cholesterol ratio (M/H ratio) on fatal and composite cardiovascular events, in an observational cohort study of chronic kidney disease (CKD) patients.
Materials and methods
A total of 340 subjects with stage 1–5 CKD were followed for a mean follow-up period of 33 (range 2–44) months and assessed for fatal and nonfatal CV events. M/H ratio was calculated for all patients. All-cause mortality and CVE were also analyzed in relation to M/H ratio.
Results
Monocyte/HDL cholesterol ratio was negatively correlated with estimated glomerular filtration rate (eGFR) (
r
= −0.43,
P
< 0.001). Notably, both fatal and combined fatal and nonfatal cardiovascular events were more common in patients having a M/H ratio in the third tertile was associated with a hazard ratio of 2.24 and 4.91, respectively, for fatal and composite cardiovascular events compared to being in the first tertile.
Conclusion
Monocyte/HDL cholesterol ratio was increased with decreasing eGFR in predialytic CKD patients. Most importantly, we report for the first time that an increased M/H ratio was cross-sectionally associated with a worse cardiovascular profile and arose as independent predictors of major cardiovascular events during follow-up.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>24853998</pmid><doi>10.1007/s11255-014-0730-1</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | International urology and nephrology, 2014-08, Vol.46 (8), p.1619-1625 |
| issn | 0301-1623 1573-2584 |
| language | eng |
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| subjects | Adult Aged Cardiovascular Diseases - blood Cardiovascular Diseases - mortality Cholesterol, HDL - blood Cross-Sectional Studies Female Glomerular Filtration Rate Humans Kaplan-Meier Estimate Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Leukocyte Count Male Medicine Medicine & Public Health Middle Aged Monocytes Myocardial Infarction - blood Myocardial Infarction - epidemiology Nephrology Nephrology - Original Paper Prospective Studies Stroke - blood Stroke - epidemiology Urology |
| title | Monocyte count/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease |
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