Monocyte count/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease

Background and aim Previous studies showed that renal dysfunction was associated with both a reduction in serum high-density lipoprotein (HDL) cholesterol concentration and increased circulating monocyte count. We aimed to investigate the effect of circulating monocyte to serum HDL cholesterol ratio (M/H ratio) on fatal and composite cardiovascular events, in an observational cohort study of chronic kidney disease (CKD) patients. Materials and methods A total of 340 subjects with stage 1–5 CKD were followed for a mean follow-up period of 33 (range 2–44) months and assessed for fatal and nonfatal CV events. M/H ratio was calculated for all patients. All-cause mortality and CVE were also analyzed in relation to M/H ratio. Results Monocyte/HDL cholesterol ratio was negatively correlated with estimated glomerular filtration rate (eGFR) ( r = −0.43, P