Pathophysiology and Clinical Application of the Renin System: Early Steps Toward Personalized Medicine

John H. Laragh was a visionary translational scientist, from bench to bedside. During his entire life, he worked on fitting together the complex cybernetic system of renin-angiotensin vasoconstriction and the commensurate angiotensin-aldosterone sodium-volume homeostasis and renal potassium control....

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Veröffentlicht in:	American journal of hypertension 2014-08, Vol.27 (8), p.996-999
1. Verfasser:	Bühler, Fritz R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood platelets Blood pressure Diuretics History of medicine History, 20th Century History, 21st Century Humans Hypertension Hypertension - drug therapy Hypertension - history Hypertension - metabolism Hypertension - physiopathology Laragh Laragh, John H Peptides Pharmaceutical industry Precision medicine Precision Medicine - history Renin - antagonists & inhibitors Renin - blood Renin-Angiotensin System Sodium Translational Medical Research - history
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Beschreibung
Zusammenfassung:	John H. Laragh was a visionary translational scientist, from bench to bedside. During his entire life, he worked on fitting together the complex cybernetic system of renin-angiotensin vasoconstriction and the commensurate angiotensin-aldosterone sodium-volume homeostasis and renal potassium control. It was John Laragh who infused subpressor doses of angiotensin into man and demonstrated the attendant rise of aldosterone secretion.1
ISSN:	0895-7061 1941-7225
DOI:	10.1093/ajh/hpu114