Efficiency of First‐Trimester Uterine Artery Doppler, A‐Disintegrin and Metalloprotease 12, Pregnancy‐Associated Plasma Protein A, and Maternal Characteristics in the Prediction of Preeclampsia

Objectives The purpose of this study was to estimate the efficiency of first‐trimester uterine artery Doppler, A‐disintegrin and metalloprotease 12 (ADAM12), pregnancy‐associated plasma protein A (PAPP‐A), and maternal characteristics in the prediction of preeclampsia. Methods We conducted a prospective cohort study of patients presenting for first‐trimester aneuploidy screening between 11 and 14 weeks' gestation. Maternal serum ADAM12 and PAPP‐A levels were measured by an immunoassay, and mean uterine artery Doppler pulsatility indices were calculated. Outcomes of interest included preeclampsia, early preeclampsia (defined as requiring delivery at