All-trans retinoic acid and rapamycin synergize with transforming growth factor- beta 1 to induce regulatory T cells but confer different migratory capacities

All-trans retinoic acid and rapamycin synergize with transforming growth factor- beta 1 to induce regulatory T cells but confer different migratory capacities

TGF- beta plus rapamycin-induced regulatory T cells (iTreg) are comparable to iTreg induced with TGF- beta plus retinoic acid in their suppressive capacity, but reveal distinct migration patterns in vivo that affect their therapeutic use.

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Veröffentlicht in:Journal of leukocyte biology 2013-11, Vol.94 (5), p.981-989
Hauptverfasser: Jhunjhunwala, Siddharth, Chen, Leo C, Nichols, Erin E, Thomson, Angus W, Raimondi, Giorgio, Little, Steven R
Format: Artikel
Sprache:eng
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Zusammenfassung:TGF- beta plus rapamycin-induced regulatory T cells (iTreg) are comparable to iTreg induced with TGF- beta plus retinoic acid in their suppressive capacity, but reveal distinct migration patterns in vivo that affect their therapeutic use.
ISSN:0741-5400
DOI:10.1189/jlb.0312167