Outbreak of pyrazinamide-monoresistant tuberculosis identified using genotype cluster and social media analysis

Outbreak of pyrazinamide-monoresistant tuberculosis identified using genotype cluster and social media analysis

SETTING:Monoresistance to pyrazinamide (PZA) has infrequently been associated with Mycobacterium tuberculosis. OBJECTIVE:To report an outbreak of PZA-monoresistant M. tuberculosis in Virginia involving two genotype clusters from December 2004 to August 2010. RESULTS:Thirty cases were identified invo...

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Veröffentlicht in:The international journal of tuberculosis and lung disease 2014-05, Vol.18 (5), p.552-558
Hauptverfasser: Thomas, T. A., Heysell, S. K., Houpt, E. R., Moore, J. L., Keller, S. J.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Antitubercular Agents - therapeutic use
Bacterial diseases
Bacteriological Techniques
Biological and medical sciences
Child
Cluster Analysis
Disease Outbreaks
DNA Fingerprinting
DNA, Bacterial - analysis
Drug Resistance
Drug Resistance, Bacterial
Female
Genotype
Human bacterial diseases
Humans
Infectious diseases
Male
Medical sciences
Microbial Sensitivity Tests
Middle Aged
Molecular Epidemiology
Mycobacterium tuberculosis
Mycobacterium tuberculosis - genetics
Pediatrics
Pnca Protein
Pneumology
Predictive Value of Tests
Pyrazinamide - therapeutic use
Retrospective Studies
Risk Factors
Social Media
Time Factors
Tuberculosis - diagnosis
Tuberculosis - drug therapy
Tuberculosis - epidemiology
Tuberculosis - transmission
Tuberculosis and atypical mycobacterial infections
Virginia
Virginia - epidemiology
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Beschreibung
Zusammenfassung:SETTING:Monoresistance to pyrazinamide (PZA) has infrequently been associated with Mycobacterium tuberculosis. OBJECTIVE:To report an outbreak of PZA-monoresistant M. tuberculosis in Virginia involving two genotype clusters from December 2004 to August 2010. RESULTS:Thirty cases were identified involving a predominantly young, US-born population with histories of substance use and incarceration and a large proportion of children aged
ISSN:1027-3719
1815-7920
DOI:10.5588/ijtld.13.0663