License to Kill Reflects Joint Action of CD4 and CD8 T Cells

The spontaneous T-cell responses to the KIF20A cancer-associated antigen found by Tomita and colleagues among peripheral blood mononuclear cells of patients with cancer, but not healthy people, involve both CD4 and CD8 T cells. Synthetic long peptides of KIF20A stimulate synergy between these two T-...

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Veröffentlicht in:	Clinical cancer research 2013-08, Vol.19 (16), p.4295-4296
1. Verfasser:	MELIEF, Cornelis J. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Epitopes, T-Lymphocyte - immunology Female Humans Kinesin - immunology Male Medical sciences Neoplasms - immunology Peptides - immunology Pharmacology. Drug treatments
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Zusammenfassung:	The spontaneous T-cell responses to the KIF20A cancer-associated antigen found by Tomita and colleagues among peripheral blood mononuclear cells of patients with cancer, but not healthy people, involve both CD4 and CD8 T cells. Synthetic long peptides of KIF20A stimulate synergy between these two T-cell types to promote cancer cell killing.
ISSN:	1078-0432 1557-3265
DOI:	10.1158/1078-0432.CCR-13-1432