IL-4 in the brain: a cytokine to remember
IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4,...
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| Veröffentlicht in: | The Journal of immunology (1950) 2012-11, Vol.189 (9), p.4213-4219 |
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| container_end_page | 4219 |
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| container_issue | 9 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 189 |
| creator | Gadani, Sachin P Cronk, James C Norris, Geoffrey T Kipnis, Jonathan |
| description | IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this cytokine appears to operate in normal brain function, and propose a hypothesis concerning its potential role in neurological pathologies. |
| doi_str_mv | 10.4049/jimmunol.1202246 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0022-1767 |
| ispartof | The Journal of immunology (1950), 2012-11, Vol.189 (9), p.4213-4219 |
| issn | 0022-1767 1550-6606 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1551619806 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Cognition - physiology Humans Inflammation - immunology Inflammation - metabolism Inflammation - pathology Interleukin-4 - cerebrospinal fluid Interleukin-4 - physiology Learning - physiology Memory - physiology Nervous System Diseases - immunology Nervous System Diseases - metabolism Nervous System Diseases - pathology Neurogenesis - immunology |
| title | IL-4 in the brain: a cytokine to remember |
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