IL-4 in the brain: a cytokine to remember

IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4,...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-11, Vol.189 (9), p.4213-4219
Hauptverfasser:	Gadani, Sachin P, Cronk, James C, Norris, Geoffrey T, Kipnis, Jonathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cognition - physiology Humans Inflammation - immunology Inflammation - metabolism Inflammation - pathology Interleukin-4 - cerebrospinal fluid Interleukin-4 - physiology Learning - physiology Memory - physiology Nervous System Diseases - immunology Nervous System Diseases - metabolism Nervous System Diseases - pathology Neurogenesis - immunology
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Beschreibung
Zusammenfassung:	IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this cytokine appears to operate in normal brain function, and propose a hypothesis concerning its potential role in neurological pathologies.
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.1202246