Phencyclidine raises kindled seizure thresholds

Phencyclidine raises kindled seizure thresholds

Phencyclidine (PCP) has been reported to have both anesthetic and seizure-inducing properties. In the present experiment the effect of PCP on previously established seizures, kindled in the amygdala, was examined, using rats as subjects. In a repeated measures design three doses of PCP (1, 2 and 5 m...

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Veröffentlicht in:Pharmacology, biochemistry and behavior biochemistry and behavior, 1982-01, Vol.16 (6), p.1009-1011
Hauptverfasser: Freeman, Frederick G., Jarvis, Michael F., Duncan, Perry M.
Format: Artikel
Sprache:eng
Schlagworte:
Amygdala
Amygdala - drug effects
Animals
Dose-Response Relationship, Drug
Kindling
Kindling, Neurologic - drug effects
Muridae
Phencyclidine
Phencyclidine - pharmacology
Seizures - chemically induced
Sensory Thresholds
Thresholds
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Zusammenfassung:Phencyclidine (PCP) has been reported to have both anesthetic and seizure-inducing properties. In the present experiment the effect of PCP on previously established seizures, kindled in the amygdala, was examined, using rats as subjects. In a repeated measures design three doses of PCP (1, 2 and 5 mg/kg) were compared with a saline control condition. The high dose of PCP was found to significantly increase seizural afterdischarge thresholds, while not affecting seizure durations.
ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(82)90062-4