Rational Design of Synthetic Nanoparticles with a Large Reversible Shift of Acid Dissociation Constants: Proton Imprinting in Stimuli Responsive Nanogel Particles

Temperature‐responsive nanogel particles with acids exhibiting large and reversible pK a shift are prepared by an ion‐imprinting polymerization of stimuli responsive monomers, cross‐linkers, and acidic monomers using protons as a template. The principles employed here should be broadly applicable to other stimuli‐responsive materials and will be an integral step in the production of active proton transporter.