Periosteum-Mimetic Structures Made from Freestanding Microgrooved Nanosheets

A “sticker‐like” PLGA nanosheet with microgrooved patterns is developed through a facile combination of spin coating and micropatterning techniques. The resulting microgrooved PLGA nanosheets can be physically adhered on flat or porous surfaces with excellent stability in aqueous environments and ca...

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Veröffentlicht in:	Advanced materials (Weinheim) 2014-05, Vol.26 (20), p.3290-3296
Hauptverfasser:	Shi, Xuetao, Fujie, Toshinori, Saito, Akihiro, Takeoka, Shinji, Hou, Ying, Shu, Yiwei, Chen, Mingwei, Wu, Hongkai, Khademhosseini, Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesiveness Animals Aqueous environments Biomimetic Materials - chemistry Bone and Bones - chemistry bone repair Bones Cell Adhesion Cells, Cultured Chickens Harnesses Humans Lactic Acid - chemistry Mesenchymal Stromal Cells - physiology micropattern Micropatterning Microscopy, Electron, Scanning nanosheet Nanostructure Nanostructures - chemistry Osteogenesis periosteum Periosteum - chemistry Polyglycolic Acid - chemistry Porosity Regenerative Spin coating Stability Tissue Scaffolds Water - chemistry
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Beschreibung
Zusammenfassung:	A “sticker‐like” PLGA nanosheet with microgrooved patterns is developed through a facile combination of spin coating and micropatterning techniques. The resulting microgrooved PLGA nanosheets can be physically adhered on flat or porous surfaces with excellent stability in aqueous environments and can harness the spatial arrangements of cells, which make it a promising candidate for generating biomimic periosteum for bone regenerative applications.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201305804