β-Cyclodextrin polymer brushes decorated magnetic colloidal nanocrystal clusters for the release of hydrophobic drugs

β-Cyclodextrin (β-CD) polymer brushes decorated magnetic Fe 3 O 4 colloidal nanocrystal clusters (Fe 3 O 4 @PG-CD) were fabricated by a combination of surface-initiated atom transfer radical polymerization on the surface of Br-anchored Fe 3 O 4 colloidal nanocrystal clusters (Fe 3 O 4 –Br) and ring-...

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Veröffentlicht in:Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2014-05, Vol.16 (5), p.1-12, Article 2393
Hauptverfasser: Lv, Shaonan, Zhao, Meiqin, Cheng, Changjing, Zhao, Zhigang
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Sprache:eng
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Zusammenfassung:β-Cyclodextrin (β-CD) polymer brushes decorated magnetic Fe 3 O 4 colloidal nanocrystal clusters (Fe 3 O 4 @PG-CD) were fabricated by a combination of surface-initiated atom transfer radical polymerization on the surface of Br-anchored Fe 3 O 4 colloidal nanocrystal clusters (Fe 3 O 4 –Br) and ring-opening reaction of epoxy groups. The resulted Fe 3 O 4 @PG-CD hybrid nanoparticles were characterized by several methods including Fourier transform infrared, transmission electron microscope, dynamic light scattering instrument, X-ray diffraction, thermogravimetric analysis, and vibrating sample magnetometer. Moreover, the potential of as-synthesized Fe 3 O 4 @PG-CD as a carrier of hydrophobic anticancer drug 5-fluorouracil (5-FU) was also investigated. The results showed that the prepared Fe 3 O 4 @PG-CD have core/shell structure and high saturated magnetism. 5-FU could be loaded into the Fe 3 O 4 @PG-CD via the formation of β-CD/5-FU inclusion complex. Furthermore, the Fe 3 O 4 @PG-CD displayed a high loading capacity and pH-dependent release behavior for 5-FU. The release behavior demonstrated a simple Fickian diffusion in the acidic environment (pH 2.0 and 4.0) but neither non-Fickian nor anomalous when neutral. The results reveal that this nanosystem seems to be a very promising vehicle for the hydrophobic drugs for pH-dependent controlled release.
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-014-2393-3