Expression of Circadian Rhythm Genes CLOCK, BMAL1, and PER1 in Buccal Epithelial Cells of Patients with Essential Arterial Hypertension in Dependence on Polymorphic Variants of CLOCK and BMAL1 Genes

The transcript levels of circadian rhythm genes CLOCK , BMAL1 , and PER1 in buccal epithelial cells of the patients with essential arterial hypertension was analyzed in relation to polymorphic variants of CLOCK and BMAL1 genes. These levels were assessed with realtime PCR method at daily hours 9, 13, and 17. The signifi cant differences were revealed in transcript levels of the examined genes in patients with various genotypes at the polymorphic markers 3111TC and 257TG regulatory regions of CLOCK gene. The study detected no signifi cant differences among the carriers of various genotypes at polymorphic markers 862TC and 2121GA of CLOCK gene and 56445TC of BMAL1 gene.