Are there differences between young- and older-onset early inflammatory arthritis and do these impact outcomes? An analysis from the CATCH cohort

Objective. The aim of this study was to determine the impact of age on disease and remission in suspected early RA (ERA). Methods. Data from the Canadian Early Arthritis Cohort (CATCH) were examined at baseline, 6 and 12 months. Patients were divided into three groups based on age. Analysis of varia...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2014-06, Vol.53 (6), p.1075-1086
Hauptverfasser:	Arnold, Michael B., Bykerk, Vivian P., Boire, Gilles, Haraoui, Boulos P., Hitchon, Carol, Thorne, Carter, Keystone, Edward C., Pope, Janet E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Age of Onset Aged Aged, 80 and over Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - diagnosis Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - epidemiology Biological Products - therapeutic use Canada - epidemiology Cohort Studies Comorbidity Drug Utilization - statistics & numerical data Female Humans Male Middle Aged Prognosis Remission Induction Severity of Illness Index Sex Factors Treatment Outcome Young Adult
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Zusammenfassung:	Objective. The aim of this study was to determine the impact of age on disease and remission in suspected early RA (ERA). Methods. Data from the Canadian Early Arthritis Cohort (CATCH) were examined at baseline, 6 and 12 months. Patients were divided into three groups based on age. Analysis of variance (ANOVA) and regression models were performed to determine the impact of age on the 28-joint DAS (DAS28) and remission at 12 months. Results. A total of 1809 patients were initially assessed: 442 (24.4%) young (
ISSN:	1462-0324 1462-0332
DOI:	10.1093/rheumatology/ket449