Lung recruitment manoeuvres do not cause haemodynamic instability or oxidative stress but improve oxygenation and lung mechanics in a newborn animal model: An observational study

BACKGROUNDLung recruitment manoeuvres in neonates during anaesthesia are not performed routinely due to concerns about causing barotrauma, haemodynamic instability and oxidative stress. OBJECTIVETo assess the influence of recruitment manoeuvres and positive end-expiratory pressure (PEEP) on haemodyn...

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Veröffentlicht in:European journal of anaesthesiology 2014-09, Vol.31 (9), p.457-465
Hauptverfasser: de la Osa, Agustín Mendiola, Garcia-Fernandez, Javier, Llorente-Cantarero, Francisco J, Gil-Campos, Mercedes, Muñoz-Villanueva, María C, De la Torre Aguilar, María J, de la Rosa, Ignacio Ibarra, Pérez-Navero, Juan L
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Sprache:eng
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Zusammenfassung:BACKGROUNDLung recruitment manoeuvres in neonates during anaesthesia are not performed routinely due to concerns about causing barotrauma, haemodynamic instability and oxidative stress. OBJECTIVETo assess the influence of recruitment manoeuvres and positive end-expiratory pressure (PEEP) on haemodynamics, oxidative stress, oxygenation and lung mechanics. DESIGNA prospective experimental study. SETTINGExperimental Unit, La Paz University Hospital, Madrid, Spain. ANIMALSEight newborn piglets (
ISSN:0265-0215
1365-2346
DOI:10.1097/EJA.0000000000000108