Assessing the suitability of miRNA-142-5p and miRNA-541 for bloodstain deposition timing

Assessing the suitability of miRNA-142-5p and miRNA-541 for bloodstain deposition timing

Highlights • 24 h day/night profiles of 2 microRNAs, proposed for death timing in vitreous humor, were determined in blood. • The application of tested miRNAs with the cortisol melatonin system for trace deposition timing was assessed. • Low levels of miRNA-541 detected in blood discourage its use f...

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Veröffentlicht in:Forensic science international : genetics 2014-09, Vol.12, p.181-184
Hauptverfasser: Lech, Karolina, Ackermann, Katrin, Wollstein, Andreas, Revell, Victoria L, Skene, Debra J, Kayser, Manfred
Format: Artikel
Sprache:eng
Schlagworte:
Forensic Genetics
Genetic Markers
MicroRNAs - blood
Pathology
Reverse Transcriptase Polymerase Chain Reaction
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Zusammenfassung:Highlights • 24 h day/night profiles of 2 microRNAs, proposed for death timing in vitreous humor, were determined in blood. • The application of tested miRNAs with the cortisol melatonin system for trace deposition timing was assessed. • Low levels of miRNA-541 detected in blood discourage its use for bloodstain deposition timing. • No rhythmicity in miRNA-142-5p expression dissuades from using this marker with the melatonin/cortisol system for blood stains.
ISSN:1872-4973
1878-0326
DOI:10.1016/j.fsigen.2014.06.008