Calcium Causes the Biphasic Dose-Response Curve for Pancreatic Amylase Secretion

Calcium Causes the Biphasic Dose-Response Curve for Pancreatic Amylase Secretion

High concentrations of bethanechol (10 super(-4) to 10 super(-3) M) were effective stimulants of amylase secretion from the mouse pancreas if incubations are performed in low (Ca super(2+)) (0.1 mM) solutions but not if normal Krebs solution (2.56 mM Ca super(2+)) was used. This inhibitory effect of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of cancer & clinical oncology 1982-01, Vol.18, p.253-260
Hauptverfasser: Roberts, M L, Woodland, MJ
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:High concentrations of bethanechol (10 super(-4) to 10 super(-3) M) were effective stimulants of amylase secretion from the mouse pancreas if incubations are performed in low (Ca super(2+)) (0.1 mM) solutions but not if normal Krebs solution (2.56 mM Ca super(2+)) was used. This inhibitory effect of Ca super(2+) at high secretagogue concentrations did not appear to be mediated through the microtubules or microfilaments.
ISSN:0277-5379