Stratified medicine approaches for the treatment of musculoskeletal disorders

Highlights • Treatments must be targeted to those who gain most benefit and least side effects. • Stratification requires identification and validation of appropriate biomarkers. • Some biomarkers for musculoskeletal disorders have been identified. • Genetic predictors are not yet validated for comm...

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Veröffentlicht in:	Current opinion in pharmacology 2014-06, Vol.16, p.127-132
Hauptverfasser:	Hocking, Lynne J, Rivadeneira, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Humans Internal Medicine Medical Education Musculoskeletal Diseases - drug therapy Musculoskeletal Diseases - genetics Musculoskeletal Diseases - metabolism
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Highlights • Treatments must be targeted to those who gain most benefit and least side effects. • Stratification requires identification and validation of appropriate biomarkers. • Some biomarkers for musculoskeletal disorders have been identified. • Genetic predictors are not yet validated for common complex diseases. • Genome-wide studies have emerging potential for risk stratification.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2014.05.003