Targeting P2 receptors—current progress in treating musculoskeletal diseases

Targeting P2 receptors—current progress in treating musculoskeletal diseases

Highlights • Various P2 receptor knockout mice have alterations in the musculoskeletal system. • P2X receptor signalling is a novel target for cancer-induced bone pain. • P2X7 receptor agonists have pharmaceutical potential in treating osteoporosis. • ADP acts as a powerful osteolytic agent via P2Y1...

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Veröffentlicht in:Current opinion in pharmacology 2014-06, Vol.16, p.122-126
Hauptverfasser: Wang, Ning, Gartland, Alison
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Bone and Bones - metabolism
Cartilage - metabolism
Humans
Internal Medicine
Medical Education
Musculoskeletal Diseases - metabolism
Neoplasms - metabolism
Receptors, Purinergic P2 - metabolism
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Zusammenfassung:Highlights • Various P2 receptor knockout mice have alterations in the musculoskeletal system. • P2X receptor signalling is a novel target for cancer-induced bone pain. • P2X7 receptor agonists have pharmaceutical potential in treating osteoporosis. • ADP acts as a powerful osteolytic agent via P2Y13 signalling. • The P2Y12 receptor antagonist Clopidogrel is associated with osteoporotic fracture.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2014.05.004