EGF-induced expression of Fused Toes Homolog (FTS) facilitates epithelial–mesenchymal transition and promotes cell migration in ME180 cervical cancer cells

Highlights • EGF induces EMT and cell migration in ME180 cervical cancer cells. • EGF induces expression of FTS through EGFR, ERK and ATF-2. • FTS silencing reduces EGF-induced EMT and cell migration.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2014-09, Vol.351 (2), p.252-259
Hauptverfasser:	Muthusami, Sridhar, Prabakaran, D.S, Yu, Jae-Ran, Park, Woo-Yoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - biosynthesis Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Apoptosis Regulatory Proteins - biosynthesis Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Cancer cell migration Cell adhesion & migration Cell Culture Techniques Cell Movement - drug effects Cell Movement - physiology Cervical cancer EGF EMT Epidermal growth factor Epidermal Growth Factor - pharmacology Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - physiology Female FTS Hematology, Oncology and Palliative Medicine Human papillomavirus Humans Kinases MMP Receptor, Epidermal Growth Factor - metabolism RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics Transfection Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology
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Beschreibung
Zusammenfassung:	Highlights • EGF induces EMT and cell migration in ME180 cervical cancer cells. • EGF induces expression of FTS through EGFR, ERK and ATF-2. • FTS silencing reduces EGF-induced EMT and cell migration.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.06.007