Triterpene Lactones from Cultures of Ganoderma sp. KM01

A revised structure of colossolactone G (1), seven new triterpene lactones, ganodermalactones A–G (2–8), and five known triterpene lactones, colossolactone I (9), schisanlactone B (10), colossolactone B (11), colossolactone E (12), and colossolactone IV (13), and ergosterol have been isolated from c...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2014-07, Vol.77 (7), p.1545-1553
Hauptverfasser:	Lakornwong, Waranya, Kanokmedhakul, Kwanjai, Kanokmedhakul, Somdej, Kongsaeree, Palangpon, Prabpai, Samran, Sibounnavong, Phoutthasone, Soytong, Kasem
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - pharmacology Crystallography, X-Ray Fruiting Bodies, Fungal - chemistry Ganoderma - chemistry Lactones - chemistry Lactones - isolation & purification Molecular Conformation Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plasmodium falciparum - drug effects Thailand Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology
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Zusammenfassung:	A revised structure of colossolactone G (1), seven new triterpene lactones, ganodermalactones A–G (2–8), and five known triterpene lactones, colossolactone I (9), schisanlactone B (10), colossolactone B (11), colossolactone E (12), and colossolactone IV (13), and ergosterol have been isolated from cultured biomass of the macrofungi Ganoderma sp. KM01. Their structures were identified by spectroscopic methods. Structures and relative configurations of 3, 7, and 8 were confirmed by X-ray crystallographic analysis. Compounds 7, 10, and 12 exhibited antimalarial activity against Plasmodium falciparum in the range 6.0–10.0 μM (IC50).
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np400846k