A molecular and structural analysis of the V sub(H) and V sub(K) regions of monoclonal antibodies bearing the A48 regulatory idiotype

A molecular and structural analysis of the V sub(H) and V sub(K) regions of monoclonal antibodies bearing the A48 regulatory idiotype

The results presented in this paper explore the molecular basis for expression of the A48 regulatory Id (RI). A48 RI super(+) mAb derived from idiotypically manipulated mice molecularly resembled the A48 and UPC 10 prototypes of this system by utilizing a V sub(H)X24-V sub(K)10 combination. Id expre...

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Veröffentlicht in:The Journal of immunology (1950) 1990-01, Vol.144 (2), p.614-624
Hauptverfasser: Victor-Kobrin, C, Barak, Z T, Bonilla, F A, Kobrin, B, Sanz, I, French, D, Rothe, J, Bona, C
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container_issue 2
container_start_page 614
container_title The Journal of immunology (1950)
container_volume 144
creator Victor-Kobrin, C
Barak, Z T
Bonilla, F A
Kobrin, B
Sanz, I
French, D
Rothe, J
Bona, C
description The results presented in this paper explore the molecular basis for expression of the A48 regulatory Id (RI). A48 RI super(+) mAb derived from idiotypically manipulated mice molecularly resembled the A48 and UPC 10 prototypes of this system by utilizing a V sub(H)X24-V sub(K)10 combination. Id expression by these antibodies was not restricted by a particular D region sequence, J sub(H), or J sub(K) segment, but quantitative differences in Id expression were associated with utilization of different members of the V sub(K)10 germline gene families.
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title A molecular and structural analysis of the V sub(H) and V sub(K) regions of monoclonal antibodies bearing the A48 regulatory idiotype
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