Serum IgG titres, but not avidity, correlates with neutralizing antibody response after H5N1 vaccination

Highlights • The H5N1 vaccines induced long-term high avidity antibodies, and IgG titres. • H5-specific serum antibody avidity continued to mature up to 12 months post-vaccination. • H5-specific serum antibody avidity did not correlate with virus microneutralization titres. • Virus microneutralizati...

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Veröffentlicht in:	Vaccine 2014-07, Vol.32 (35), p.4550-4557
Hauptverfasser:	Pedersen, Gabriel Kristian, Höschler, Katja, Øie Solbak, Sara Marie, Bredholt, Geir, Pathirana, Rishi Delan, Afsar, Aram, Breakwell, Lucy, Nøstbakken, Jane Kristin, Raae, Arnt Johan, Brokstad, Karl Albert, Sjursen, Haakon, Zambon, Maria, Cox, Rebecca Jane
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adult Allergy and Immunology Antibodies, Neutralizing - blood Antibodies, Viral - blood Antibody Affinity Antibody avidity Antibody response Applied microbiology Avian flu Avidity Biological and medical sciences Clinical trials Correlation Elution Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Humans IgG antibody Immunization Immunoglobulin G Immunoglobulin G - blood Immunological memory Influenza Influenza A Virus, H5N1 Subtype - immunology Influenza H5N1 Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Injections, Intramuscular ISCOM Long term memory Lymphocytes B Matrix M Memory cells Microbiology Middle Aged Miscellaneous Neutralization Neutralization Tests Pandemic influenza Pandemics Serum - immunology Sodium thiocyanate Studies Surface Plasmon Resonance Vaccination Vaccination - methods Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virology Virosomal vaccine Virus neutralization Viruses Young Adult
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Beschreibung
Zusammenfassung:	Highlights • The H5N1 vaccines induced long-term high avidity antibodies, and IgG titres. • H5-specific serum antibody avidity continued to mature up to 12 months post-vaccination. • H5-specific serum antibody avidity did not correlate with virus microneutralization titres. • Virus microneutralization correlated with H5-specific serum IgG antibody titres.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.06.009