Pneumococcal carriage in children and adults two years after introduction of the thirteen valent pneumococcal conjugate vaccine in England

Pneumococcal carriage in children and adults two years after introduction of the thirteen valent pneumococcal conjugate vaccine in England

Highlights • In April 2010 PCV7 was replaced by PCV13. • We investigated pneumococcal carriage in children and their household contacts. • Carriage of PCV13 serotypes rapidly reduced in vaccinated and unvaccinated. • Carriage rates in children remain unchanged. • Low case carrier rates of replacing...

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Veröffentlicht in:Vaccine 2014-07, Vol.32 (34), p.4349-4355
Hauptverfasser: van Hoek, Albert Jan, Sheppard, Carmen L, Andrews, Nick J, Waight, Pauline A, Slack, Mary P.E, Harrison, Timothy G, Ladhani, Shamez N, Miller, Elizabeth
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Age
Allergy and Immunology
Applied microbiology
Bacteriology
Biological and medical sciences
Carriage
Carrier State - epidemiology
Carrier State - microbiology
Child
Child, Preschool
Colonisation
Confidence intervals
Conjugate vaccine
Ear diseases
England - epidemiology
Female
Fundamental and applied biological sciences. Psychology
Herd immunity
Households
Humans
Immunization
Infant
Longitudinal Studies
Male
Microbiology
Middle Aged
Miscellaneous
Nasopharynx
Nasopharynx - microbiology
Pneumococcal Infections - epidemiology
Pneumococcal Infections - prevention & control
Pneumococcal Vaccines - administration & dosage
Pneumococcus
Post-PCV13
Prevalence
Serotyping
Streptococcus infections
Streptococcus pneumoniae
Streptococcus pneumoniae - classification
Vaccine impact
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Conjugate - administration & dosage
Young Adult
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Beschreibung
Zusammenfassung:Highlights • In April 2010 PCV7 was replaced by PCV13. • We investigated pneumococcal carriage in children and their household contacts. • Carriage of PCV13 serotypes rapidly reduced in vaccinated and unvaccinated. • Carriage rates in children remain unchanged. • Low case carrier rates of replacing serotypes should further reduce overall IPD.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.03.017