Pharmacological Profiles of Acute Myeloid Leukemia Treatments in Patient Samples by Automated Flow Cytometry: A Bridge to Individualized Medicine
Micro-Abstract We have estimated the pharmacological sensitivity and synergism of 125 individual patient samples for all drugs and combination treatments for acute myeloid leukemia in the context of the overall patient population. Each ex vivo pharmacological profile identifies drugs and treatments...
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| Veröffentlicht in: | Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2014-08, Vol.14 (4), p.305-318 |
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| creator | Bennett, Teresa A Montesinos, Pau Moscardo, Federico Martinez-Cuadron, David Martinez, Joaquin Sierra, Jorge García, Raimundo de Oteyza, Jaime Perez Fernandez, Pascual Serrano, Josefina Fernandez, Angeles Herrera, Pilar Gonzalez, Ataulfo Bethancourt, Concepcion Rodriguez-Macias, Gabriela Alonso, Arancha Vera, Juan A Navas, Begoña Lavilla, Esperanza Lopez, Juan A Jimenez, Santiago Simiele, Adriana Vidriales, Belen Gonzalez, Bernardo J Burgaleta, Carmen Hernandez Rivas, Jose A Mascuñano, Raul Cordoba Bautista, Guiomar Perez Simon, Jose A Fuente, Adolfo de la Rayón, Consolación Troconiz, Iñaki F Janda, Alvaro Bosanquet, Andrew G Hernandez-Campo, Pilar Primo, Daniel Lopez, Rocio Liebana, Belen Rojas, Jose L Gorrochategui, Julian Sanz, Miguel A Ballesteros, Joan |
| description | Micro-Abstract We have estimated the pharmacological sensitivity and synergism of 125 individual patient samples for all drugs and combination treatments for acute myeloid leukemia in the context of the overall patient population. Each ex vivo pharmacological profile identifies drugs and treatments for which the patient's malignant cells are particularly sensitive or resistant, assisting in the selection of individualized treatments. |
| doi_str_mv | 10.1016/j.clml.2013.11.006 |
| format | Article |
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| subjects | Adult Aged Aged, 80 and over Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Bone Marrow Cells - drug effects Bone Marrow Cells - pathology Cell Survival - drug effects Chemosensitivity Dose-Response Relationship, Drug Drug Monitoring Drug Resistance, Neoplasm Drug Synergism Ex vivo Female Flow Cytometry Hematology, Oncology and Palliative Medicine Humans Individualized tumor response to testing Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - drug therapy Male Middle Aged Personalized medicine Precision Medicine Treatment Outcome |
| title | Pharmacological Profiles of Acute Myeloid Leukemia Treatments in Patient Samples by Automated Flow Cytometry: A Bridge to Individualized Medicine |
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