Pharmacological Profiles of Acute Myeloid Leukemia Treatments in Patient Samples by Automated Flow Cytometry: A Bridge to Individualized Medicine

Micro-Abstract We have estimated the pharmacological sensitivity and synergism of 125 individual patient samples for all drugs and combination treatments for acute myeloid leukemia in the context of the overall patient population. Each ex vivo pharmacological profile identifies drugs and treatments...

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Veröffentlicht in:	Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2014-08, Vol.14 (4), p.305-318
Hauptverfasser:	Bennett, Teresa A, Montesinos, Pau, Moscardo, Federico, Martinez-Cuadron, David, Martinez, Joaquin, Sierra, Jorge, García, Raimundo, de Oteyza, Jaime Perez, Fernandez, Pascual, Serrano, Josefina, Fernandez, Angeles, Herrera, Pilar, Gonzalez, Ataulfo, Bethancourt, Concepcion, Rodriguez-Macias, Gabriela, Alonso, Arancha, Vera, Juan A, Navas, Begoña, Lavilla, Esperanza, Lopez, Juan A, Jimenez, Santiago, Simiele, Adriana, Vidriales, Belen, Gonzalez, Bernardo J, Burgaleta, Carmen, Hernandez Rivas, Jose A, Mascuñano, Raul Cordoba, Bautista, Guiomar, Perez Simon, Jose A, Fuente, Adolfo de la, Rayón, Consolación, Troconiz, Iñaki F, Janda, Alvaro, Bosanquet, Andrew G, Hernandez-Campo, Pilar, Primo, Daniel, Lopez, Rocio, Liebana, Belen, Rojas, Jose L, Gorrochategui, Julian, Sanz, Miguel A, Ballesteros, Joan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Bone Marrow Cells - drug effects Bone Marrow Cells - pathology Cell Survival - drug effects Chemosensitivity Dose-Response Relationship, Drug Drug Monitoring Drug Resistance, Neoplasm Drug Synergism Ex vivo Female Flow Cytometry Hematology, Oncology and Palliative Medicine Humans Individualized tumor response to testing Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - drug therapy Male Middle Aged Personalized medicine Precision Medicine Treatment Outcome
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Zusammenfassung:	Micro-Abstract We have estimated the pharmacological sensitivity and synergism of 125 individual patient samples for all drugs and combination treatments for acute myeloid leukemia in the context of the overall patient population. Each ex vivo pharmacological profile identifies drugs and treatments for which the patient's malignant cells are particularly sensitive or resistant, assisting in the selection of individualized treatments.
ISSN:	2152-2650 2152-2669
DOI:	10.1016/j.clml.2013.11.006