How do we treat fetal and neonatal alloimmune thrombocytopenia?

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a potentially devastating disease, seen in one in 800 to 1000 neonates. FNAIT is the most common cause of early‐onset isolated severe neonatal thrombocytopenia in maternity wards. The complication of this disorder most to be feared is intracr...

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Veröffentlicht in:Transfusion (Philadelphia, Pa.) Pa.), 2014-07, Vol.54 (7), p.1698-1703
Hauptverfasser: Bertrand, Gérald, Kaplan, Cécile
Format: Artikel
Sprache:eng
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Zusammenfassung:Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a potentially devastating disease, seen in one in 800 to 1000 neonates. FNAIT is the most common cause of early‐onset isolated severe neonatal thrombocytopenia in maternity wards. The complication of this disorder most to be feared is intracranial hemorrhage, leading to death or to neurologic sequels. As there is no systematic screening of at‐risk pregnancies, FNAIT is often discovered when signs of bleeding are observed during pregnancy or at delivery. Platelet transfusion is required in case of bleeding or severe thrombocytopenia (
ISSN:0041-1132
1537-2995
DOI:10.1111/trf.12671