Resistance to neoplastic transformation induced by nonterminal differentiation

Cell clones derived from undifferentiated 3T3 T mesenchymal stem cells show a low rate of spontaneous transformation but can be efficiently transformed by a variety of carcinogens. In contrast, it is now reported that cell clones derived from nonterminally differentiated 3T3 T stem cells are highly...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1989-02, Vol.49 (4), p.1008-1013
Hauptverfasser:	ESTERVIG, D. N, MAERCKLEIN, P. B, SCOTT, R. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogens - pharmacology Cell Cycle Cell Differentiation - drug effects Cell Division Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic - drug effects Cells, Cultured Clone Cells Drug Resistance Fundamental and applied biological sciences. Psychology Mice Mice, Inbred BALB C Models, Biological Molecular and cellular biology Ultraviolet Rays
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Zusammenfassung:	Cell clones derived from undifferentiated 3T3 T mesenchymal stem cells show a low rate of spontaneous transformation but can be efficiently transformed by a variety of carcinogens. In contrast, it is now reported that cell clones derived from nonterminally differentiated 3T3 T stem cells are highly resistant to neoplastic transformation induced by physical and chemical carcinogens. Differentiation-induced resistance to neoplastic transformation is evident in both in vitro and in vivo transformation assays and can be stably expressed for greater than 50 population doublings. These results establish that resistance to neoplastic transformation can be regulated in mammalian stem cells by the process of nonterminal differentiation.
ISSN:	0008-5472 1538-7445