Drug selectivity: Running in the family

Comprehensive selectivity profiling is key for the development of safe drugs. Few current methods are capable of profiling large compound sets against entire target classes. The new EnPlex method expands the existing toolbox, allowing for the surveying of the serine hydrolase enzyme family. A study...

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Veröffentlicht in:	Nature chemical biology 2014-08, Vol.10 (8), p.608-609
Hauptverfasser:	Muelbaier, Marcel, Drewes, Gerard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biotechnology Dipeptidyl-Peptidase IV Inhibitors - pharmacology Enzyme Inhibitors - pharmacology Enzymes Female High-Throughput Screening Assays - methods Humans Male Pharmacology
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Comprehensive selectivity profiling is key for the development of safe drugs. Few current methods are capable of profiling large compound sets against entire target classes. The new EnPlex method expands the existing toolbox, allowing for the surveying of the serine hydrolase enzyme family. A study by Bachovchin et al that developed this method is discussed.
ISSN:	1552-4450 1552-4469
DOI:	10.1038/nchembio.1585