Rate of increase in serum lactate level risk-stratifies infants after surgery for congenital heart disease

Objective Increased blood lactate levels reflect tissue oxygen debt and might be indicative of low cardiac output. We hypothesized that the rate of increase in serum lactate would be an ideal marker to discriminate between infants at high and low risk of a poor outcome after surgical repair of conge...

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Veröffentlicht in:	The Journal of thoracic and cardiovascular surgery 2014-08, Vol.148 (2), p.589-595
Hauptverfasser:	Schumacher, Kurt R., MS, MD, Reichel, Rebecca A., BS, Vlasic, Jeffrey R., MS, Yu, Sunkyung, MS, Donohue, Janet, MPH, Gajarski, Robert J., MD, Charpie, John R., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis, Lactic - blood Acidosis, Lactic - diagnosis Acidosis, Lactic - etiology Acidosis, Lactic - mortality Age Factors Area Under Curve Biomarkers - blood Cardiac Surgical Procedures - adverse effects Cardiac Surgical Procedures - mortality Cardiopulmonary Bypass Cardiothoracic Surgery Female Heart Defects, Congenital - blood Heart Defects, Congenital - diagnosis Heart Defects, Congenital - mortality Heart Defects, Congenital - surgery Humans Infant Infant, Newborn Intensive Care Units, Pediatric Lactic Acid - blood Male Predictive Value of Tests Prospective Studies Risk Assessment Risk Factors ROC Curve Time Factors Treatment Outcome Up-Regulation
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Zusammenfassung:	Objective Increased blood lactate levels reflect tissue oxygen debt and might be indicative of low cardiac output. We hypothesized that the rate of increase in serum lactate would be an ideal marker to discriminate between infants at high and low risk of a poor outcome after surgical repair of congenital heart disease using cardiopulmonary bypass. Methods In the present prospective, observational study in a pediatric cardiac intensive care unit, infants (aged
ISSN:	0022-5223 1097-685X
DOI:	10.1016/j.jtcvs.2013.09.002